TOPIC

Neurological research

Everything we have read on neurological. Each paper is summarised from the full article rather than its abstract, so the limitations are in there too, and the funding wherever the paper declares it.

3,875 PAPERS · PAGE 37 OF 78 · NEWEST FIRST

• PTProtocol2022Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy AssociationNo results are reported. This paper outlines the methods for a future study assessing brain connectivity and motor outcomes in infants with perinatal brain injury using MRI, TMS, and standardized developmental tests. It describes what the researchers plan to do, not what they found.
• PTOTQualitative2022The COVID-19 Pandemic Related Lived Experiences of Individuals With a Spinal Cord Injury/Disease.Frontiers in rehabilitation sciencesPeople with spinal cord injury said pandemic rules made mobility, home care, social interaction and health care harder, while telehealth, physical activity and social connection helped them cope.
• PTOTSLPCohort2022Co-occurring conditions and racial-ethnic disparities: Medicaid enrolled adults on the autism spectrum.Autism research : official journal of the International Society for Autism ResearchMedicaid-enrolled autistic adults had higher rates of most mental health conditions and several physical ones, but lower rates of others like stroke and cerebral palsy. Significant racial-ethnic disparities existed in both physical and mental health diagnoses compared to white autistic adults.
• PTOTSLPQualitative2022Participatory co-creation of an adapted physical activity program for adults with moderate-to-severe traumatic brain injury.Frontiers in rehabilitation sciencesAdults with moderate-to-severe TBI valued a 9-month community gym program for its structure, peer support, and clear visual aids. They reported feeling more capable and autonomous, with barriers like fatigue and social comparison easing over time.
• PTOTNarrative Review2022Predicting Individual Treatment Response to rTMS for Motor Recovery After Stroke: A Review and the CanStim Perspective.Frontiers in rehabilitation sciencesPotential predictors of better rTMS response after stroke include purely subcortical lesions, preserved motor pathways, and the BDNF Val/Val genotype, but evidence is inconsistent and many studies were small or uncontrolled.
• PTOther2022Effect of trim line on stiffness in dorsi- and plantarflexion of posterior leaf spring ankle-foot orthoses.Journal of physical therapy scienceWidening the posterior upright of a polypropylene ankle-foot orthosis increased its dorsiflexion moment in plantarflexion. Narrower uprights reduced that moment. Trim width was linked to stiffness. This bench test did not measure patients walking.
• PTOther2022Soleus H and Lower Limb Posterior Root Muscle Reflexes During Stepping After Incomplete SCI.Frontiers in rehabilitation sciencesAfter spinal cord injury, soleus reflexes remain larger and modulate less during stepping than in non-injured people. The H reflex tracks motor scores, but the broader posterior root muscle reflex does not, meaning these two tests measure different things.
• PTOTCohort2022Relationship among trunk control, activities of daily living, and upper extremity function during the first week after stroke in patients with acute cerebral infarction.Journal of physical therapy scienceTrunk control strongly correlated with daily living ability and arm function within 7 days of stroke. Trunk control and age predicted daily living ability, with trunk control being the stronger factor. Early trunk assessment is critical for planning acute stroke rehabilitation.
• PTOTSystematic Review2022Adaptations in Muscular Strength for Individuals With Multiple Sclerosis Following Robotic Rehabilitation: A Scoping Review.Frontiers in rehabilitation sciencesRobot-assisted lower-limb training increased leg strength in all three lower-limb studies; one of two upper-limb studies increased grip force. Strength was not the main target in these five small studies, so it is not proven as a stand-alone strength treatment.
• PTOTSLPCohort2022Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality.Frontiers in rehabilitation sciencesAdding botulinum toxin to oromotor therapy improved sleep and swallowing more than therapy alone in children with cerebral palsy. The toxin group saw greater reductions in sleep breathing disorders and difficulty falling asleep.
• PTOTRCT2021The Effect of Whole-Body Vibration on Proprioception and Motor Function for Individuals with Moderate Parkinson Disease: A Single-Blind Randomized Controlled Trial.Occupational therapy internationalWhole-body vibration did not improve proprioception or outperform conventional therapy in moderate Parkinson's disease. Both groups showed short-term gains in motor function and balance, suggesting vibration is a viable passive alternative for those unable to engage in active movement.
• PTOTPilot2022Robotic Rehabilitation and Transcranial Direct Current Stimulation in Children With Bilateral Cerebral Palsy.Frontiers in rehabilitation sciencesFive children with bilateral cerebral palsy completed 10 days of robotic arm training plus transcranial direct current stimulation. It was feasible and tolerated, but the study did not test whether arm function improved. Three children stopped, and training time fell as sessions continued.
• PTOTSLPQualitative2022Factors related to sustainable employment of people with acquired brain injury or spinal cord injury: The employer's perspective.Frontiers in rehabilitation sciencesEmployers said keeping staff with brain or spinal injury depends on matching tasks to ability and open communication. They valued job coaches to bridge gaps, especially when invisible cognitive issues or self-awareness problems arise.
• PTOTQualitative2022Designing a trial of early electrical stimulation to the stroke-affected arm: Qualitative findings on the barriers and facilitators.The British journal of occupational therapyTherapists perceived time and lack of confidence as major barriers to early electrical stimulation, but patients confidently self-managed the treatment and found it acceptable. Patients reported insufficient staff support due to ward pressures. This highlights a disconnect between clinician concerns and patient experience.
• PTSurvey2022Current knowledge and practice of post-stroke unilateral spatial neglect rehabilitation: A cross-sectional survey of South African neurorehabilitation physiotherapists.The South African journal of physiotherapyAmong 28 valid respondents, South African neurorehabilitation physiotherapists had moderate knowledge of post-stroke unilateral spatial neglect, half used standard screening tools, and inadequate time and equipment were major barriers.
• PTOTSLPNarrative Review2022Somesthetic, Visual, and Auditory Feedback and Their Interactions Applied to Upper Limb Neurorehabilitation Technology: A Narrative Review to Facilitate Contextualization of Knowledge.Frontiers in rehabilitation sciencesAugmented sensory feedback can support upper limb stroke recovery, but more is not always better. Match feedback type to the patient's specific deficits and task complexity, and fade it over time to avoid dependency and maintain challenge.
• PTOTSLPCohort2022Assessment of Manual Abilities Using the Box and Block Test in Children with Bilateral Cerebral Palsy.Occupational therapy internationalIn children with bilateral cerebral palsy, Box and Block Test scores strongly predicted daily living performance. Scores of 28 to 40 blocks indicated a high probability of managing independent wiping. Low scores suggest looking for environmental barriers or cognitive factors rather than just motor limits.
• PTOTSLPSystematic Review2022Conceptualization of Participation: A Qualitative Synthesis of Brain Injury Stakeholder Perspectives.Frontiers in rehabilitation sciencesPeople with brain injury define participation by choice, contribution, and feeling included, not just by completing tasks. Social relationships and leisure were cited far more often than work. These subjective elements often do not fit standard impairment-focused outcome measures.
• PTOTSLPCase Report2022Ankle dorsiflexion training with a newly developed Hybrid Assistive Limb for a patient with foot drop caused by common peroneal nerve palsy: a case report.Journal of physical therapy scienceOne man with foot drop from nerve damage showed stronger ankle movement and a normal gait after seven sessions with an ankle exoskeleton. However, he also received standard rehab, so the device's specific benefit cannot be separated from natural recovery or other therapy.
• PTOTCase Report2022Brain-Computer Interface Priming for Cervical Transcutaneous Spinal Cord Stimulation Therapy: An Exploratory Case Study.Frontiers in rehabilitation sciencesIn one person with chronic cervical spinal cord injury, adding brain-computer interface priming before spinal cord stimulation did not clearly improve hand function more than stimulation alone. Gains occurred in both phases, but independence in daily activities did not change.
• PTOTSLPQualitative2022Play-based groups for children with cerebral palsy and their parents: A qualitative interview study about the impact on mothers' well-being.Child: care, health and developmentMothers of children with cerebral palsy valued play-based groups for practical help with therapy and education plans, and for connecting with others in similar situations. Some struggled to open up due to language barriers or guilt, showing the need for sensitive facilitation.
• PTOTQualitative2022Self-Management Embedded in Daily Activities: A Photoelicitation Focus Group Study among Persons with Spinal Cord Injury and Their Primary Caregivers in Bangladesh.Occupational therapy internationalPeople with spinal cord injury and caregivers in Bangladesh described managing daily life through routines, activity, emotional coping, roles, and tackling stigma. They moved to friendlier places, asserted rights, advocated access, and used income, faith, charity, and peers.
• PTOTSLPOther2022The Effects of Occupation-Based Community Rehabilitation for Improving Activities of Daily Living and Health-Related Quality of Life of People with Disabilities after Stroke Living at Home: A Single Subject Design.Occupational therapy internationalThree people with severe disabilities after stroke living at home improved daily life independence and quality of life after a community-based occupational therapy programme. The programme combined task training, home changes, education and resource linking, so the effect of any single part cannot be separated.
• PTQualitative2022Understanding Acceptability, Barriers, and Facilitators to Clinical Implementation of the on Track Developmental Monitoring System for Children with Cerebral Palsy: A Qualitative Study.Physical & occupational therapy in pediatricsClinicians valued comparing children with cerebral palsy with peers at the same gross motor level, not typical development. They wanted more hands-on training, digital scoring, and help with time, reimbursement, and policy barriers.
• PTSurvey2022Diagnostic preferences include discussion of etiology for adults with cerebral palsy and their caregivers.Developmental medicine and child neurologyAmong adults with cerebral palsy and caregivers with a preference, most wanted a cerebral palsy label with a genetic cause. They valued cerebral palsy for services, community, and explaining symptoms, and many wanted to know the cause.
• PTOTOther2022Optimization of machine learning method combined with brain-computer interface rehabilitation system.Journal of physical therapy scienceIn 8 stroke patients, 4 weeks of brain-computer interface training with a robot improved upper limb scores and reduced spasticity. Brain imaging suggested neural reshaping, but the tiny sample and lack of a control group mean this is a technical proof of concept, not evidence of efficacy.
• PTOTSLPRCT2022Effects of exercise on sleep spindles in Parkinson's disease.Frontiers in rehabilitation sciencesExercise did not change sleep spindle density or amplitude across the whole night in people with Parkinson's disease. It did slow a decline in spindle density during the first half of the night, and this change correlated with better memory scores in the exercise group only.
• PTOTSystematic Review2022Influences on Participation in Life After Spinal Cord Injury: Qualitative Inquiry Reveals Interaction of Context and Moderators.Frontiers in rehabilitation sciencesPeople with spinal cord injury described participation as shaped by physical and social barriers, body functions, psychological meaning, control, knowledge, support, resources and timing. These themes can guide person-centred rehabilitation, but the review does not test interventions.
• PTOTSLPCohort2022Risk factors for decline in gait speed during walking while talking in older adults.Gait & postureWalking speed while talking declined faster in older adults who were older, had poorer balance, or had faster single-task walking speeds. Poor balance was the strongest modifiable risk factor for this accelerated decline.
• PTOTPilot2022Utility of an obstacle-crossing test to classify future fallers and non-fallers at hospital discharge after stroke: A pilot study.Gait & postureStroke survivors who failed to step over a customized obstacle before hospital discharge were three times more likely to fall in the next three months. This simple test may help identify those needing extra fall prevention, though results are not precise enough for routine practice yet.
• PTOTCohort2022Impact of Falls and Fear of Falling on Participation, Autonomy and Life Satisfaction in the First Year After Spinal Cord Injury.Frontiers in rehabilitation sciencesAfter discharge, falling alone was not linked to participation or life satisfaction. Fear of falling was linked to lower indoor, outdoor and family autonomy; falling with fear was linked to poorer social life and lower life satisfaction.
• PTOTSLPCohort2022Long-term neurodevelopmental outcome of neonates born at term with perinatal haemorrhagic stroke: A population-based study.Developmental medicine and child neurologyMost infants with perinatal haemorrhagic stroke had lasting neurodevelopmental issues. Parietal lobe involvement strongly predicted cerebral palsy and cognitive deficits. Frontal lobe strokes showed no motor or basic cognitive impairment, suggesting better outcomes for that group.
• PTOther2022Do sensorimotor control properties mediate sway in people with chronic balance complaints following mTBI?Gait & postureIn people with chronic balance complaints after mild traumatic brain injury, corrective motor output and response delay were linked to reported impairment and sway. Sensory cue weighting was not. This points to motor timing but does not prove balance training helps.
• PTOTRCT2022Effectiveness of Repetitive Facilitative Exercise Combined with Electrical Stimulation Therapy to Improve Very Severe Paretic Upper Limbs in with Stroke Patients: A Randomized Controlled Trial.Occupational therapy internationalPatients with very severe arm paralysis who combined repetitive exercise with electrical stimulation showed greater gains in hand and finger function than those receiving conventional therapy alone. No other treatment group improved significantly more than the control, and proximal shoulder function did not differ between groups.
• PTOTNarrative Review2022Effects of voluntary exercise on muscle structure and function in cerebral palsy.Developmental medicine and child neurologyResistance training builds muscle size in children with cerebral palsy, but increasing muscle power requires fast concentric movements. High-velocity training increased fascicle length and walking capacity, while standard strength training often failed to improve functional mobility.
• PTOTCohort2022A Prediction Model for Various Treatment Pathways of Upper Extremity in Tetraplegia.Frontiers in rehabilitation sciencesMotor point mapping and ASIA scores taken 4 to 8 weeks after cervical spinal cord injury predict hand muscle strength at 6 months. Intact lower motor neurons and AIS C or D scores strongly indicate that patients will develop useful voluntary movement.
• PTOTSLPPilot2022Operant down-conditioning of the soleus H-reflex in people after stroke.Frontiers in rehabilitation sciencesHalf of stroke survivors successfully reduced a spinal reflex through training. Those who succeeded walked faster by 0.14 m/s on average. The other half did not improve reflex size, but their walking speed did not worsen either.
• PTOTSLPCohort2022The Interrelationship of Tinnitus and Hearing Loss Secondary to Age, Noise Exposure, and Traumatic Brain Injury.Ear and hearingHearing loss is the strongest risk factor for tinnitus, increasing risk 4.15 times. Tinnitus often precedes measurable hearing loss, suggesting it may be an early warning sign. Veterans over 40 with tinnitus have an 80% likelihood of developing hearing difficulties.
• PTOTCase Series2022Feasibility and Acceptability of Game-Based Cortical Priming and Functional Lower Limb Training in a Remotely Supervised Home Setting for Chronic Stroke: A Case Series.Frontiers in rehabilitation sciencesThree chronic stroke survivors completed 24 home sessions of game-based ankle priming and lower limb training remotely. All showed walking speed gains meeting the minimal clinically important difference. The program was feasible and safe, but without a control group, efficacy remains unproven.
• PTOTSLPQualitative2022Facilitators and Barriers to Sustainable Employment After Spinal Cord Injury or Acquired Brain Injury: The Person's Perspective.Frontiers in rehabilitation sciencesPeople with spinal cord or acquired brain injury described sustainable work as depending on accessible, flexible workplaces, supportive colleagues, and confidence to explain their needs. Insurance delays and invisible fatigue were major barriers.
• PTOTSurvey2022Exploring problems for school reintegration following spinal cord injury: Perspectives on the kindergarten through fifth-grade population.Frontiers in rehabilitation sciencesChildren with spinal cord injury often return to school needing new support plans. Physical therapy was the most common need, followed by occupational therapy and counseling. Access barriers remain frequent, and many parents did not know their child's injury level.
• PTOTCase Report2022Improvement in lower extremity hemiplegia in a post-operative brain tumor patient by applying an integrated volitional control electrical stimulator.Journal of physical therapy scienceA man with post-surgical leg paralysis walked faster after IVES gait training, improving from 10.9 to 9.43 seconds over 10 meters. Balance and muscle control also changed, but this single case cannot prove the device works for others.
• PTOTQualitative2022Empowerment, Communication, and Navigating Care: The Experience of Persons With Spinal Cord Injury From Acute Hospitalization to Inpatient Rehabilitation.Frontiers in rehabilitation sciencesPatients with spinal cord injury reported needing to advocate aggressively for their own care and education. They found hospital staff often lacked empathy or specialized knowledge, leaving them unprepared for discharge and forcing them to rely on family and peers to navigate community resources.
• PTOTOther2022Effect of Haptic Training During Manual Wheelchair Propulsion on Shoulder Joint Reaction Moments.Frontiers in rehabilitation sciencesHaptic training raised pushrim force effectiveness but also increased shoulder joint loads. The absolute rise was small, under 10% of maximum effort. Short-term use appears safe, but long-term injury risk remains unknown.
• PTOTSLPCohort2022Eating and drinking ability and nutritional status in adults with cerebral palsy.Developmental medicine and child neurologyNearly a third of adults with cerebral palsy have eating and drinking difficulties. Those needing help at meals weighed significantly less, even after adjusting for motor function. Low body weight is linked to mealtime dependence, not just physical disability.
• PTOTCase Series2022Brachial plexus birth injury and cerebral palsy lead to a common contracture phenotype characterized by reduced functional muscle length and strength.Frontiers in rehabilitation sciencesIn ten children with cerebral palsy or brachial plexus injury, affected elbows showed weak muscles that were also functionally short. This suggests contractures stem from impaired muscle growth rather than excess strength, pointing toward lengthening treatments.
• PTOTSurvey2022Caregiver assessment of quality of life in individuals with genetic developmental and epileptic encephalopathies.Developmental medicine and child neurologyCaregiver-reported quality of life in genetic developmental and epileptic encephalopathies tracked days minimally disrupted by seizures, medication side effects, and diagnosis burden, not seizure frequency.
• PTOTOther2022Functional and Structural Brain Connectivity in Children With Bilateral Cerebral Palsy Compared to Age-Related Controls and in Response to Intensive Rapid-Reciprocal Leg Training.Frontiers in rehabilitation sciencesIntensive leg training did not change brain structure or connectivity in children with bilateral cerebral palsy. Training improved speed on the device but did not improve walking speed. Small sample size and motion artifacts limit confidence in these null findings.
• PTOTQualitative2022A focus group study of therapists' views on using a novel neuroanimation virtual reality game to deliver intensive upper-limb rehabilitation early after stroke.Archives of physiotherapyTherapists found virtual reality games engaging but felt their own active presence was essential for success. They warned that without dedicated time, training, and technical support, such intensive therapy is difficult to sustain in routine practice.
• PTSurvey2022Knowledge, Attitudes, and Practice of Pelvic Floor Muscle Training in People With Spinal Cord Injury: A Cross-Sectional Survey.Frontiers in rehabilitation sciencesPeople with spinal cord injury know about pelvic floor muscle training and want to learn more, but very few have actually done it. Most said a clinician never discussed it with them, and men were less likely to know how to access it than women.