TOPIC

Neurological research

Everything we have read on neurological. Each paper is summarised from the full article rather than its abstract, so the limitations are in there too, and the funding wherever the paper declares it.

3,875 PAPERS · PAGE 62 OF 78 · NEWEST FIRST

• PTOTSLPPilot2025Co-designing and testing a management programme with peer support for post-stroke fatigue: Nottingham fatigue after stroke study (NotFAST3).Clinical rehabilitationStroke survivors with fatigue and trained peer supporters tested a self-management programme. Participants reported feeling supported and found the workbook helpful. Fatigue and mood scores improved, but without a control group, it is unknown if the programme caused these changes.
• PTOTSLPPilot2025The Spinal Cord Injury Self-Management Program: A Pilot.OTJR : occupation, participation and healthA 6-week virtual self-management program for spinal cord injury was feasible and acceptable to participants. It showed positive effects on secondary health conditions and goal attainment, but self-efficacy scores decreased, possibly due to participants understanding the challenges better after the intervention.
• PTOTPilot2025Preparing Adults with Cerebral Palsy to Move from Assisted to Independent Living.Canadian journal of occupational therapy. Revue canadienne d'ergotherapieSeven adults with severe cerebral palsy improved their ability to manage daily tasks like cooking and finances after a 20-week coaching program. The intervention helped them reach personal goals and increased confidence in using powered wheelchairs.
• PTCohort2025Are the 6-minute walk test and the 2-minute walk test equivalent in acute and subacute stroke survivors in Belgium and Vietnam: a multicultural study.Journal of rehabilitation medicineIn 119 acute and subacute stroke survivors who could walk independently, the 2-minute walk test showed similar stroke-related distance reduction, speed, and heart-rate response to the 6-minute test, with high repeat-test consistency.
• PTOTSLPOther2025Components of frontal assessment battery and clinical features in patients with stroke.Journal of rehabilitation medicineMost stroke patients scored well on frontal lobe tests, but a small group had severe executive dysfunction. This group showed specific deficits in behavioural control and attention tasks, yet their daily independence and general cognition scores were similar to others. Screening total scores may miss this specific impairment.
• PTNarrative Review2025TECAR Therapy: A Clinical Commentary on its Evolution, Application, and Future in Rehabilitation.International journal of sports physical therapyThis article reviews the theoretical basis and existing literature on TECAR therapy for musculoskeletal and neurological conditions. It highlights the lack of large, standardized trials and does not present new evidence to support or refute the treatment's efficacy.
• PTOTOther2025Age-related trajectories of muscle strength and power in individuals with cerebral palsy and the relationship to walking capacity.Gait & postureKnee muscle power tracks walking speed better than raw strength in cerebral palsy. Unlike typical development, muscle strength and power do not keep pace with body mass growth from childhood to adulthood in this population.
• PTOTSystematic Review2025Manual wheelchair training approaches and intended training outcomes for adults who are new to wheelchair use: A scoping review.Australian occupational therapy journalMost wheelchair training programs for adults focus on basic skills, confidence, and propulsion mechanics rather than long-term community participation. They rarely address the needs of older adults with progressive conditions or those with cognitive impairments, leaving therapists without clear guidance on effective, tailored approaches.
• PTPilot2025High-Intensity Gait Training for Patients After Stroke: A Feasibility Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapyHigh-intensity gait training was feasible for 15 severely impaired stroke patients, including non-ambulatory ones. Most completed at least eight sessions with no serious adverse events. Patients reported high satisfaction. Gait measures improved, but without a control group, the training's specific effect cannot be separated from natural recovery or other rehab.
• PTOTSurvey2025Motivation Matters: Elucidating Factors Driving Exercise in People With Parkinson Disease.Physical therapyMost people with Parkinson disease who exercise are motivated by wanting to stay independent and seeing physical benefits, not by external rewards. Fatigue is the top barrier. Prior exercise habits and self-compassion predict current motivation more strongly than disease severity or age.
• PTCase Report2025Spinal cord injury and electrical stimulation: analysis of neuroplasticity in a case report.Frontiers in rehabilitation sciencesBoth patients with spinal cord injury showed neurological and muscle activation changes during neuromuscular electrical stimulation. With no control or comparison, the paper cannot show the stimulation caused these changes.
• PTOTNarrative Review2025Exploring the Landscape of Biomarkers in Spinal Cord Injury.Topics in spinal cord injury rehabilitationSpinal cord injury lacks FDA-approved biomarkers for predicting recovery, so clinicians must still rely on the ISNCSCI exam despite its variability. This review maps emerging candidates like serum proteins and MRI tissue bridges, but none are ready for routine clinical use yet.
• PTOTSLPCohort2025Examining and comparing the clinical characteristics of adults with persisting post-concussion symptoms presenting for outpatient rehabilitation following a mild traumatic brain injury or a minimal head injury.Journal of rehabilitation medicinePatients referred to rehab with persisting symptoms after a mild head injury report similar high symptom burdens and disability whether their injury met criteria for mild TBI or was even milder. Nearly half had no loss of consciousness or amnesia. Treat symptoms and function, not just injury severity.
• PTOTSLPOther2024A Delphi Exploration of Toileting Activity Performance in Individuals With Cerebral Palsy Within the ICF-CY Framework: Unveiling Influential Factors.Occupational therapy internationalExperts agreed that caregiver awareness of a child's readiness and neuromusculoskeletal function are the top factors affecting toileting in cerebral palsy. They also highlighted the critical role of toilet environment, communication feedback, and cultural attitudes toward menstruation and hygiene.
• PTOTOther2025Exploratory development of human-machine interaction strategies for post-stroke upper-limb rehabilitation.Journal of neuroengineering and rehabilitationA new upper-limb exoskeleton accurately recognized subtle movement intentions in healthy volunteers (99.7% accuracy) and stopped safely when excessive force was applied in a single post-stroke patient. Clinical trials are needed to confirm rehabilitation effectiveness.
• PTOTOther2025Neuroimaging and biological markers of different paretic hand outcomes after stroke.Journal of neuroengineering and rehabilitationA brain scan metric called ALFF accurately distinguished stroke patients with partial hand weakness from those with complete paralysis. It also predicted hand function scores. This suggests a potential tool for assessing recovery, but clinical use requires further validation.
• PTOTPilot2025Wristful thinking: exploring the effects of robotic rehabilitation and cross-education for persons with multiple sclerosis.Journal of neuroengineering and rehabilitationIn people with MS, robot-guided wrist training of a single arm increased wrist strength and tracking accuracy in both arms, but daily hand function scores did not change.
• PTOTRCT2025Effectiveness of a rehabilitation program involving functional proprioceptive stimulation for postural control and motor recovery among stroke patients: a double-blinded, randomized, controlled trial.Journal of neuroengineering and rehabilitationWith physiotherapy, standing practice and daily-activity training in both groups, adding real focal vibration improved balance more than sham vibration in stroke patients.
• PTRCT2025Effect of the Kickstart exoskeleton lower extremity walking system on improving lower extremity walking ability in subacute stroke patients: a randomized controlled trial.Journal of neuroengineering and rehabilitationIn subacute stroke, adding Kickstart to conventional rehab improved lower-limb motor scores more at 4 and 8 weeks, but gait speed, stride length and symmetry did not differ between groups.
• PTRCT2025Electromyography (EMG)-triggered transcutaneous spinal cord and hip stimulation for gait rehabilitation in persons with chronic stroke: a randomized, controlled trial.Journal of neuroengineering and rehabilitationNo significant difference was found between groups in 10-m walking time after adding EMG-triggered spinal and hip stimulation to treadmill training. The combined group improved within itself, but that alone does not show it beats treadmill training.
• PTOTCohort2025Multicenter study on predictors of rehabilitation outcome and home discharge in people with non-traumatic spinal cord injuries.European journal of physical and rehabilitation medicineFunctional scores at discharge predicted going home better than scores at admission in people with non-traumatic spinal cord injury. Longer stay, higher admission score, younger age, being married, and no central venous catheter were linked to home discharge.
• PTOTRCT2025Different light color temperatures in the morning on the effectiveness of rehabilitation training in patients with ischemic stroke: a prospective, single-center, randomized controlled clinical trial.Journal of neuroengineering and rehabilitationMorning exposure to cold light (6500 K) during rehabilitation improved neurological function, sleep quality, and physical health scores in stroke patients compared to warm or standard light. Warm light showed no benefit over standard conditions. The effect was seen after four weeks of morning sessions.
• PTOTOther2025Psychometric validation of comprehensive coordination scale to assess the advanced coordination ability in people with stroke.European journal of physical and rehabilitation medicineThe Comprehensive Coordination Scale reliably measures motor coordination in chronic stroke survivors. A total score below 62.5 effectively distinguishes those with stroke from healthy older adults. However, the scale's bilateral and unaffected-side subscores showed poor reliability or diagnostic power.
• PTOTCase Report2025Effects of body weight-supported overground training on gait recovery in severe stroke-induced hemiplegia: a single-case ABAB design.Journal of physical therapy scienceA woman with severe stroke-related paralysis walked faster and took fewer steps when body weight-supported overground training was added to standard therapy. Her walking speed rose to 0.58 m/s during the training phase, dropping when it stopped and rising again when it resumed.
• PTOther2025Impact of Individual Factors on Exercise Dose During a Walking Intervention in People With Stroke.Journal of neurologic physical therapy : JNPTPeople with chronic stroke grouped by walking endurance, daily steps, comorbidity, balance confidence, and depression still reached similar treadmill walking dose during a 12-week high-intensity program. Baseline profiles did not predict attained exercise dose.
• PTPilot2025A personalised, gait training telerehabilitation programme for people with Parkinson's Disease: A long-term pilot study.Clinical rehabilitationNine-month home gait training was safe and feasible for people with Parkinson's, but overall adherence missed the 75% target. Those with moderate disease stuck to it and showed some improvement; those with advanced disease struggled to keep up and reported lower satisfaction.
• PTCase Series2025Radiographic Findings in the Lower Extremity Joints of Long-Term Users of Implanted Standing Neuroprostheses with Spinal Cord Injuries.Archives of rehabilitation research and clinical translationNo lower-extremity joint showed a significant change in arthritis grade in four long-term users of implanted standing neuroprostheses after spinal cord injury over an average of 51 months.
• PTOTCohort2025The Longitudinal Course of Physical Activity Behavior Poststroke and Its Variation Across Subgroups: The Norwegian Cognitive Impairment After Stroke Study.Physical therapyStroke survivors' physical activity declined steadily over three years. A quarter of participants remained in the least active group, with only the most active group meeting step recommendations. No subgroup increased activity over time, suggesting early intervention is critical to prevent long-term decline.
• PTOTMeta-Analysis2025Upper limb robotic rehabilitation following stroke: a systematic review and meta-analysis investigating efficacy and the influence of device features and program parameters.Journal of neuroengineering and rehabilitationDose-matched robotic therapy gave a tiny, short-lived boost to arm capacity that patients did not feel in daily life. It did not beat conventional therapy for activities. Games and feedback added nothing when a therapist supervised the session.
• PTOTSLPOther2025Item-Level Psychometrics for the Functional Gait Assessment in Persons With Stroke.Archives of rehabilitation research and clinical translationThe Functional Gait Assessment measures one thing in chronic stroke: walking balance. A new scoring sheet lets therapists see exactly which tasks a patient can handle and which are just out of reach, guiding treatment targets without needing to calculate complex statistics.
• PTOTSLPCase Series2025Effect of Dual-Task Training on the Number of EEG Bands in Stroke Patients.Physiotherapy research international : the journal for researchers and clinicians in physical therapyFive women with stroke showed reduced brain wave activity in all four EEG bands after 12 sessions of dual-task training. All improved on manual dexterity tests, but the authors state these clinical changes cannot yet be considered relevant or proven effective.
• PTOTMeta-Analysis2025Clinical relevance of the effects of robotic rehabilitation for upper limb recovery after stroke in randomized studies: a systematic review with meta-analysis.Archives of physiotherapyRobot-assisted upper limb training after stroke did not produce benefits large enough for patients to consider clinically important, despite gains in daily activities, dexterity, arm function, and strength over control therapy.
• PTOTSLPCohort2025Amantadine Continuation After Hospital Discharge for Acute Stroke Requiring Inpatient Rehabilitation: A Long-term Follow-up Study.Archives of rehabilitation research and clinical translationIn 28 stroke patients continuing amantadine into rehab, dosing varied widely but appeared safe. Most patients improved in mobility and speech, yet confusion and agitation often emerged when doses were reduced, not increased. This offers no guidance on optimal dosing or timing.
• PTOTCohort2025Investigating Balance Perception and Balance Performance in Neurological Disorders for Targeted Rehabilitation Strategies.Physical therapyFor people with Parkinson disease and stroke, confidence in daily activities linked strongly to dynamic balance tasks like stairs and turning. For multiple sclerosis, links were weak. Prioritize dynamic gait and sensory challenges for PD and stroke; results for MS are less clear.
• PTOTSLPSystematic Review2025A Systematic Scoping Review of Poststroke Engagement in Physical Activity.Archives of rehabilitation research and clinical translationCommunity-dwelling stroke survivors typically walk about 4000 steps a day, falling short of guidelines. Objective measures show lower activity than self-reports. Interventions with coaching or education increased activity in the short term, but long-term adherence and support quality remain unclear.
• PTOTCohort2025Safety and Effectiveness of Early Rehabilitation in Patients With Stroke and Concomitant Kidney Disease: A Cohort Study With Claims Data.Archives of rehabilitation research and clinical translationStarting rehabilitation 24 to 48 hours after admission did not increase death rates or shorten hospital stays compared to starting later. The primary outcome was null for both chronic kidney disease and end-stage kidney disease groups.
• PTOTRCT2025Variants of active assist robotic therapy: feasibility of virtual assistance and proprioceptive training as gauged by their effects on success and motivation during finger movement training after stroke.Journal of neuroengineering and rehabilitationTwo new robotic hand-training modes kept stroke survivors engaged and successful. Virtual assistance worked without physical support, but users felt less competent than those with physical help. Proprioceptive games were harder and less enjoyable, though still feasible with high assistance.
• PTQualitative2025'Feeling like you can't do anything because you don't know where to start'-Parents' Perspectives of Barriers and Facilitators to Accessing Early Detection for Children at Risk of Cerebral Palsy.Child: care, health and developmentMothers of children referred late to cerebral palsy early detection services described feeling lost, unsupported, and forced to become advocates. They said plain language information, stable relationships, and clearer referral pathways would have helped.
• PTOTSystematic Review2025Mapping of ultrasonography methods and shoulder soft-tissue injury locations in patients with stroke: a scoping review.Journal of rehabilitation medicineUltrasonography is rarely used to map shoulder soft-tissue injuries after stroke. When it is, clinicians consistently use a linear probe at 5–7 MHz with the patient sitting. The most common findings are biceps tendon effusion and supraspinatus tears.
• PTOTCase Report2025Case Report: Rehabilitation assessment and exercise using cardiopulmonary exercise test after coronavirus-disease pneumonia.Frontiers in rehabilitation sciencesTwo men with persistent respiratory distress after severe COVID-19 improved their exercise tolerance and oxygen needs after rehabilitation guided by cardiopulmonary exercise testing. They completed a multi-component programme including respiratory training and prone positioning, so the specific contribution of the testing protocol cannot be isolated.
• PTSystematic Review2025Dual Task Training Interventions and Mobility-Based Outcomes in Children with Cerebral Palsy: A Scoping Review.Physical & occupational therapy in pediatricsDual task training may improve balance, walking, gross motor function and functional mobility in children with cerebral palsy. Six studies cannot show which dose works, and no study measured performance change when tasks are done together.
• PTOTQualitative2025The use of robotic upper limb therapy in routine clinical practice for stroke survivors: Insights from Australian therapists.Australian occupational therapy journalNine therapists accepted robot arm therapy as extra practice for stroke survivors with dense arm weakness, but occupational therapists used it less because the device sat in the physiotherapy gym.
• PTSystematic Review2025Measurement properties of observational gait analysis in patients with stroke: a systematic review.Journal of physical therapy scienceFour observational gait tools for stroke patients show varying reliability and validity, but most studies had methodological flaws. Video recording protocols were inconsistent across studies, making it difficult to standardize assessments or compare results reliably in clinical practice.
• PTCohort2025The effect of physical therapy with goal attainment scaling on gait function in patients with subacute stroke.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liaoSubacute stroke patients whose gait goal was met or exceeded showed larger gains in walking, balance, strength and daily mobility. This is an association after mixed rehabilitation, not proof goal setting caused the gains.
• PTOTCohort2025Prediction of independent ambulation in subacute stroke patients: a retrospective observational study using lower limb motor and balance assessments.Journal of rehabilitation medicineAdmission scores on the Berg Balance Scale and Fugl-Meyer lower limb test predicted independent walking at discharge in subacute stroke patients. A Berg score of 38.5 or higher on admission best identified those likely to walk independently.
• PTOTRCT2025Effects and neural mechanisms of a brain-computer interface-controlled soft robotic glove on upper limb function in patients with subacute stroke: a randomized controlled fNIRS study.Journal of neuroengineering and rehabilitationAdding brain-computer interface control to a soft robotic glove improved arm movement scores more than the glove alone in subacute stroke patients. However, this did not translate to better independence in daily activities, and the study was small and short-term.
• PTCase Report2025Changes in gait parameters using two types of step training in a patient following hemiplegic stroke.Journal of physical therapy scienceIn one patient recovering from stroke, anterior-posterior step training improved gait symmetry, but platform step training worsened walking speed and symmetry. This suggests platform training may hinder forward propulsion in early recovery, while specific floor-based steps can help.
• PTOTPilot2025Cross-cultural adaptation and validation of the Japanese translation of the Fugl-Meyer Assessment for upper and lower extremity sensorimotor function after stroke.Journal of rehabilitation medicineThe Japanese Fugl-Meyer Assessment was translated and tested in 10 patients with chronic stroke. Raters agreed on most items, with agreement above 90% for the majority. Only two sensation items showed scoring inconsistencies, which were corrected in the final version.
• PTOTSLPCohort2025The proportion and clinical characteristics of patients with stroke who returned to work six months after discharge from a convalescent rehabilitation ward: a descriptive study.Frontiers in rehabilitation sciencesTwo-thirds of working-age stroke patients returned to work six months after discharge. Those who did not return had higher rates of aphasia and lower cognitive scores, even when motor function and daily living skills were similar to those who returned.
• PTOTSLPCohort2025Delayed inpatient rehabilitation and functional outcomes for acute stroke: a retrospective cohort study in an Australian regional hospital.Journal of rehabilitation medicineStroke patients waiting more than 24 hours for a rehab bed after being medically ready gained less function relative to their potential and recovered more slowly. These delays, mostly caused by bed shortages, also led to longer hospital stays. Timely admission matters for functional recovery.