TOPIC

Neurological research

Everything we have read on neurological. Each paper is summarised from the full article rather than its abstract, so the limitations are in there too, and the funding wherever the paper declares it.

2,792 PAPERS · PAGE 12 OF 56 · NEWEST FIRST

• OTSLPCohort2019Traumatic Microbleeds in the Hippocampus and Corpus Callosum Predict Duration of Posttraumatic Amnesia.The Journal of head trauma rehabilitationCorpus callosum microbleeds correlated with post-traumatic amnesia duration, while hippocampal microbleeds only trended. A model using microbleeds, GCS, and age did not account for all variation, so this is not yet a clinical predictor.
• OTSLPOther2019Rey Tangled Line Test: A measure of processing speed in TBI.Rehabilitation psychologyIn 100 people with TBI, Rey Tangled Line Test time related to processing speed and motor scores, not accuracy. Test scores did not differ by injury severity.
• PTOTPilot2019Immersive Virtual Reality Mirror Therapy for Upper Limb Recovery After Stroke: A Pilot Study.American journal of physical medicine & rehabilitationTen chronic stroke survivors tolerated immersive virtual reality mirror therapy without adverse events or significant cybersickness. Motor scores improved slightly but not significantly. The study confirms safety and feasibility but does not show the treatment works.
• PTOTCohort2019Does pre-existing cognitive impairment impact on amount of stroke rehabilitation received? An observational cohort study.Clinical rehabilitationStroke inpatients with documented pre-existing cognitive impairment received fewer physiotherapy and occupational therapy sessions: 16 fewer on average, but 9 fewer after accounting for age, sex, stroke severity and pre-stroke disability.
• PTOTSLPCohort2020Changing Healthcare and School Needs in the First Year After Traumatic Brain Injury.The Journal of head trauma rehabilitationUnmet or unrecognized health care needs were 22% at 3 months, with 13% unrecognized and 7% unmet at 12 months. Needs shifted from physical to cognitive and socioemotional, and combined health care or school need was 28% at 3 months and 24% at 12 months.
• PTOTSLPRCT2019Stroke patients' and non-professional coaches' experiences with home-based constraint-induced movement therapy: a qualitative study.Clinical rehabilitationChronic stroke patients and their family coaches described home-based constraint-induced movement therapy as hard to fit into daily life due to time and fatigue. While some valued the shared effort, others found the coaching stressful. Patients often struggled with the immobilizing glove and had unmet expectations for rapid recovery.
• PTOTSLPPilot2019A short bout of high-intensity exercise alters ipsilesional motor cortical excitability post-stroke.Topics in stroke rehabilitationFive minutes of fast treadmill walking increased brain excitability in the damaged hemisphere in stroke survivors. This short priming bout may prepare the brain for therapy, but the study did not show that it improves actual movement or function.
• PTOTOther2019Neural Correlates of Passive Position Finger Sense After Stroke.Neurorehabilitation and neural repairRobotic testing found finger proprioception deficits in 67% of stroke survivors' contralesional hands, far exceeding the 26% detected by standard clinical scales. Deficits were best explained by combined sensory system injury and functional connectivity, not motor damage alone.
• OTRCT2019Bilateral Contralaterally Controlled Functional Electrical Stimulation Reveals New Insights Into the Interhemispheric Competition Model in Chronic Stroke.Neurorehabilitation and neural repairOne hour of bilateral stimulation driven by the strong hand reduced the non-lesioned side's braking of the lesioned side and kept lesioned-side output steady, unlike unilateral stimulation. The same-side pathway did not differ between sessions. This is physiology, not hand recovery proof.
• OTSurvey2019Insomnia prevalence among U.S. Army soldiers with history of TBI.Rehabilitation psychologyInsomnia was common among active-duty Army soldiers: 39.1% overall, 37.5% without TBI history, and 55.7% with moderate to severe TBI. Sleep problems increased with self-reported injury severity.
• PTOTSLPCohort2019Resilience facilitates adjustment through greater psychological flexibility among Iraq/Afghanistan war veterans with and without mild traumatic brain injury.Rehabilitation psychologyVeterans with resilient personality traits had better mental health and function over a year, largely because they had greater psychological flexibility. This protective effect held true regardless of whether the veteran had a history of mild traumatic brain injury.
• OTCohort2020Predictors of Change in Employment Status and Associations with Quality of Life: A Prospective International Study of People with Multiple Sclerosis.Journal of occupational rehabilitationAmong people with MS, moderate or severe disability and lower education predicted losing employment over 2.5 years. Retiring because of MS was associated with a drop in mental health quality of life. So watch for mood changes after job loss.
• PTOTSLPCohort2020The Impact of One's Sex and Social Living Situation on Rehabilitation Outcomes After a Stroke.American journal of physical medicine & rehabilitationAfter adjusting for age and severity, women recovering from stroke discharged with greater functional independence than men on most measures. Living alone before the stroke also predicted better outcomes, suggesting this reflects higher pre-stroke capability rather than lack of support.
• PTOTPilot2019The effect of electrical stimulation on impairment of the painful post-stroke shoulder.Topics in stroke rehabilitationIn 10 people, applying TENS or t-NMES for 10 seconds during passive shoulder movement did not make the painful post-stroke shoulder move further before pain began. The three conditions gave almost the same range.
• OTCohort2019Depression as a Predictor of Long-term Employment Outcomes Among Individuals With Moderate-to-Severe Traumatic Brain Injury.Archives of physical medicine and rehabilitationDepression after moderate-to-severe TBI was associated with lower long-term competitive employment. People who were depressed at 1 or 2 years were less likely to be employed at 2 or 5 years, even after accounting for injury-related prognosis and current work.
• PTOTCohort2020Subgroups Defined by the Montreal Cognitive Assessment Differ in Functional Gain During Acute Inpatient Stroke Rehabilitation.Archives of physical medicine and rehabilitationStroke patients grouped by Montreal Cognitive Assessment at rehab admission differed in functional gains. Those scoring 25 to 30 made the most gain per day; those scoring 19 or below made the least, and fewer reached a 22-point FIM gain.
• PTOTOther2019A Revised Motor Activity Log Following Rasch Validation (Rasch-Based MAL-18) and Consensus Methods in Chronic Stroke and Multiple Sclerosis.Neurorehabilitation and neural repairA revised 18-item Motor Activity Log gives therapists a clearer way to rate how well a person with stroke or MS uses their affected arm in daily life. It removes items that are not universally applicable and includes a table to convert scores.
• PTOTOther2019Utilization of Rehabilitation Services in Stroke: A Study Utilizing the Health and Retirement Study With Linked Medicare Claims Data.Archives of physical medicine and rehabilitationAmong older Medicare stroke survivors, only 21.6% reported rehabilitation at first poststroke interview. Older age and a second stroke were linked to more use.
• OTRCT2019Advantages of using 3D virtual reality based training in persons with Parkinson's disease: a parallel study.Journal of neuroengineering and rehabilitationCompared with a 2D screen, a 3D headset did not show a clear clinical test advantage in Parkinson's disease. It was more motivating and led to faster task performance, while both groups improved.
• PTOTCohort2019Upper Limb Performance in Daily Life Improves Over the First 12 Weeks Poststroke.Neurorehabilitation and neural repairUpper limb use in daily life improved over the first 12 weeks post-stroke, especially in those with low initial capacity. Belief, confidence, and motivation were already high and did not predict improvement. Early therapy may better target self-perceived barriers than psychosocial factors.
• PTOTOther2019Breaking Proportional Recovery After Stroke.Neurorehabilitation and neural repairStroke arm recovery that looks proportional is partly a score artifact. Rule-breaking patients mostly fail wrist, hand, shoulder, and finger-to-nose items. Mid-range chronic scorers improved more in published arm practice trials.
• OTQualitative2020The Experience of Caregivers Following a Moderate to Severe Traumatic Brain Injury Requiring ICU Admission.The Journal of head trauma rehabilitationCaregivers of people with moderate to severe brain injury wanted clear early updates, help with unknown prognosis, and support before discharge. Over months, burden shifted to daily care, scheduling, mobility, and emotional strain.
• PTOTOther2019Absence of Motor-Evoked Potentials Does Not Predict Poor Recovery in Patients With Severe-Moderate Stroke: An Exploratory Analysis.Archives of rehabilitation research and clinical translationStroke patients with no motor-evoked potential still improved after intensive upper-limb therapy, but less than patients who had one. Adding nerve or brain stimulation was not clearly better than sham.
• PTOTOther2019Movement smoothness during a functional mobility task in subjects with Parkinson's disease and freezing of gait - an analysis using inertial measurement units.Journal of neuroengineering and rehabilitationPeople with Parkinson's and freezing of gait, off medication, had less smooth movement during a Timed Up and Go test, especially when turning, even though few showed freezing during the test. A waist sensor captured this, and smoothness tracked clinical scores.
• OTPilot2020Differences among participants' response to a wellness intervention for individuals with spinal cord injuries.Disability and health journalIn this small analysis, single or divorced participants and those under 50 were more likely to not respond to a wellness program for spinal cord injury. This does not prove the program works, but suggests who might need different support.
• PTOTOther2020Functional Deficits in the Less-Impaired Arm of Stroke Survivors Depend on Hemisphere of Damage and Extent of Paretic Arm Impairment.Neurorehabilitation and neural repairChronic stroke survivors' less-affected arm was slower and less effective on hand tasks, especially when the paretic arm was severely impaired. Left hemisphere damage slowed writing and feeding. This does not show training helps.
• PTOTSLPNarrative Review2019What the Proportional Recovery Rule Is (and Is Not): Methodological and Statistical Considerations.Neurorehabilitation and neural repairA rule that people recover a fixed share of upper-limb function after stroke may describe group averages, but reviewed studies do not prove it predicts any one patient.
• PTOTCase Report2019Cryoneurotomy as a Percutaneous Mini-invasive Therapy for the Treatment of the Spastic Limb: Case Presentation, Review of the Literature, and Proposed Approach for Use.Archives of rehabilitation research and clinical translationIn three patients with chronic spasticity, cryoneurotomy of specific motor nerves improved range of motion and reduced muscle tone. In two elbow cases, this procedure allowed botulinum toxin doses to be redistributed to other muscles, yielding further functional gains.
• PTOTSLPCohort2019Social Network Mapping and Functional Recovery Within 6 Months of Ischemic Stroke.Neurorehabilitation and neural repairStroke survivors’ social networks shrank by an average of 1.25 people over six months. However, having a larger network at baseline predicted better physical function at three and six months, independent of stroke severity, age, or depression.
• PTOTOther2020The six-minute walk test as a fall risk screening tool in community programs for persons with stroke: a cross-sectional analysis.Topics in stroke rehabilitationIn 66 adults with chronic stroke, walking under 331.65 m on the six-minute walk test was associated with being in an increased fall risk group. It is a screening association, not proof it predicts actual falls.
• OTProtocol2019Behavioral Activation Augmented With Mobile Technology for Depression and Anxiety in Chronic Moderate-Severe Traumatic Brain Injury: Protocol for a Randomized Controlled Trial.Archives of rehabilitation research and clinical translationNo patient outcomes are reported yet. The protocol plans to test whether eight behavioral activation sessions with app prompts and texts improve depression or anxiety after chronic traumatic brain injury, compared with one in-person session, one telephone session, and eight weeks of texts.
• OTOther2019A Collaboration Between Game Developers and Rehabilitation Researchers to Develop a Web-Based App for Persons With Physical Disabilities: Case Study.JMIR rehabilitation and assistive technologiesRehabilitation researchers, game developers, and stakeholders developed a web app for people with spinal cord injury. The report describes accessibility choices and team lessons, not evidence that the app improves mental health or well-being.
• PTOTSLPCohort2020Volunteering and its association with participation and life satisfaction following traumatic brain injury.Brain injuryVolunteering after brain injury is linked to better life satisfaction, more community engagement, and more social contact. It is not linked to productivity like work or school hours. People who volunteer tend to have less severe impairments and drive independently.
• PTOTCohort2019Association Between SCIM III Total Scores and Individual Item Scores to Predict Independence With ADLs in Persons With Spinal Cord Injury.Archives of rehabilitation research and clinical translationHigher SCIM III total scores were linked to a greater chance of independence in daily tasks. Feeding and indoor mobility were easier to reach. Stair climbing and some transfers needed much higher scores.
• PTOTSystematic Review2019Exoskeletons With Virtual Reality, Augmented Reality, and Gamification for Stroke Patients' Rehabilitation: Systematic Review.JMIR rehabilitation and assistive technologiesMost studies reported motor gains with exoskeletons plus VR or games, but samples were small and varied, mostly clinic-based. No single device or game setup is established.
• OTCase-Control2019Integrated robotics platform with haptic control differentiates subjects with Parkinson's disease from controls and quantifies the motor effects of levodopa.Journal of neuroengineering and rehabilitationA robot arm test separated Parkinson's disease from controls. People off medication moved 41% slower and hit 25% fewer targets. After medication, motor and robot scores improved, but rigidity measures did not track the clinical change.
• OTCohort2020Factors associated with the remission of insomnia after traumatic brain injury: a traumatic brain injury model systems study.Brain injuryIn 40 people with insomnia after moderate or severe TBI, those whose insomnia resolved reported better sleep quality, less fatigue and depression, and more community participation than those with persistent insomnia. Medication use was similar, so this cannot show what caused remission.
• PTOTSLPSurvey2020Effects of Chronic Brain Injury on Quality of Life: A Study in Patients With Left- or Right-Sided Lesion.Archives of rehabilitation research and clinical translationPeople with chronic focal brain injury reported quality of life in 5 areas, and left hemisphere injury was linked to worse perceived cognitive functioning even when standard cognitive tests did not differ.
• PTOTSLPCase-Control2020Subtle Motor Signs and Executive Functioning in Chronic Paediatric Traumatic Brain Injury: Brief Report.Developmental neurorehabilitationChildren with chronic traumatic brain injury showed subtle motor deficits that correlated with executive function problems. A bedside motor exam may help flag which children need further cognitive testing.
• PTOTOther2019Vision does not always help stroke survivors compensate for impaired limb position sense.Journal of neuroengineering and rehabilitationVision does not reliably help stroke survivors with impaired limb position sense. While some fully compensated, many showed only partial or no improvement. This challenges the common assumption that watching the affected limb solves proprioceptive deficits.
• OTOther2019Harnessing smartphone technology and three dimensional printing to create a mobile rehabilitation system, mRehab: assessment of usability and consistency in measurement.Journal of neuroengineering and rehabilitationOlder adults and people with stroke rated a smartphone and 3D printed home practice system as easy to learn and relevant to daily tasks. The app counted movements correctly, but day-to-day measurement was inconsistent for some activities.
• OTPilot2019Home used, patient self-managed, brain-computer interface for the management of central neuropathic pain post spinal cord injury: usability study.Journal of neuroengineering and rehabilitationPeople with spinal cord injury and chronic central pain could self-manage a home neurofeedback headset, but eight of fifteen who tried it stopped. Twelve reported lower pain, and eight had a drop larger than 30%. This was not a controlled test.
• PTOTRCT2019Effects of virtual reality-based planar motion exercises on upper extremity function, range of motion, and health-related quality of life: a multicenter, single-blinded, randomized, controlled pilot study.Journal of neuroengineering and rehabilitationAdding 30 minutes of virtual reality planar motion to standard occupational therapy was safe but did not improve arm movement more than standard therapy alone. Patients reported better quality of life and recovery perception, but the small pilot size means these benefits are not yet proven.
• OTPilot2020The Value in Mental Health Screening for Individuals With Spinal Cord Injury: What Patients Tell Us.Archives of rehabilitation research and clinical translationPatients with spinal cord injury found mental health screening acceptable and intended to follow recommendations, but described the process as incomplete. They concealed substance use and felt the questions missed their personal strengths and resilience.
• PTOTQualitative2020A qualitative study on user acceptance of a home-based stroke telerehabilitation system.Topics in stroke rehabilitationStroke patients who used a home telerehabilitation system combining games, exercises, education, and therapist video sessions valued feedback and connection, and found games enjoyable. They wanted reliable technical support, flexible schedules, and visible progress.
• PTOTPilot2019Leap motion controlled video game-based therapy for upper limb rehabilitation in patients with Parkinson's disease: a feasibility study.Journal of neuroengineering and rehabilitationLeap Motion games did not show a clear advantage over conventional therapy on grip strength or Box and Blocks dexterity, but did produce better Purdue Pegboard scores. In 23 people with Parkinson's, both groups reported high satisfaction and attended all 12 sessions.
• PTOTOther2019Detecting compensatory movements of stroke survivors using pressure distribution data and machine learning algorithms.Journal of neuroengineering and rehabilitationIn eight stroke survivors, a pressure-distribution mattress and machine learning classified trunk lean-forward, trunk rotation and shoulder elevation during seated reaching, and the patterns matched trunk muscle activity.
• PTOTSLPNarrative Review2019Models of Traumatic Brain Injury in Aged Animals: A Clinical Perspective.Neurorehabilitation and neural repairPreclinical TBI research overwhelmingly uses young animals, leaving a gap in understanding how aging and common comorbidities like diabetes or hypertension affect recovery. Current animal models fail to replicate the clinical reality of elderly patients, limiting the translation of new treatments to geriatric care.
• PTOTOther2019Model for prompt and effective classification of motion recovery after stroke considering muscle strength and coordination factors.Journal of neuroengineering and rehabilitationStroke patients differed from healthy people in how muscle signals were balanced between sides and shared among muscles. Patients with the same impairment score could have different muscle problems, so a score may not guide therapy choice.
• OTOther2019SenseJoy, a pluggable solution for assessing user behavior during powered wheelchair driving tasks.Journal of neuroengineering and rehabilitationA new plug-in device measures joystick movements without disassembling the wheelchair. It matched direct measurements in tests with 13 users. This allows therapists to objectively assess driving skills and identify user profiles in real-world settings.