Intraindividual variability in post-stroke cognition and its relationship with activities of daily living and social functioning: an ecological momentary assessment approach.
Elizabeth G S Munsell, Quoc Bui, Katherine J Kaufman and 9 others
PMID 38278142WHAT IT FOUND
In 202 mild-to-moderate stroke survivors, people whose self-reported cognitive problems varied more across the day had worse daily activities and social functioning.
Standardized cognitive tests did not show the same differences.
Key findings
01The 202 participants were grouped into three classes of within-person cognitive problem variability: low, moderate, and high.
02Participants in the moderate and high cognitive variability classes had significantly more activities of daily living and social functioning problems than the low variability class; 36-71% of the moderate class and 29-100% of the high class met clinical cutoffs.
03Standardized neuropsychological tests did not significantly separate the classes, although the high variability class had more participants meeting working-memory (43%) and executive-function (64%) cutoffs than the moderate class (21%, 41%) and the low class (22%, 7%).
STILL TO COME
How it was doneWhat they foundWhat it means for OTs
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What it does not show
The study did not assign participants to treatments or follow them after an intervention, so it can show association but not cause. The high variability class had only 14 participants, which may have reduced power to detect differences in neuropsychological and functional outcomes. The sample was community-dwelling and had mild-to-moderate stroke, so it may not apply to acute stroke or more severe disability. Cognitive variability was measured with only two self-report questions, which may not capture all aspects of cognition. Standardized neuropsychological tests were designed to measure overall cognitive capacity, not day-to-day variability, so a mismatch between self-report and testing is expected. Self-reported cognitive variability may be influenced by environment, pain, fatigue, depression, or stress, but the study did not test these factors. Ten participants were excluded for completing less than 30% of surveys and 14 dropped out before completion, so the analysed group may differ from those who did not complete the protocol.
Declared interests
No conflicts of interest statement is included in the supplied text. The article metadata lists NIH extramural and non-U.S. government research support.
The easy way to misread this
Do not read this paper as proof that cognitive variability causes worse daily living or social functioning, or that ecological momentary assessment screening will improve outcomes. The study did not assign participants to treatments or test an intervention, and the high variability group had only 14 participants, so the findings describe differences between groups, not treatment effects.