Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy.
Christine Miaskowski, Steven M Paul, Judy Mastick and 11 others
PMID 29353626WHAT IT FOUND
Cancer survivors with chemotherapy-induced neuropathy who also reported hearing loss and tinnitus had worse balance, pain interference, mood, and quality of life than those with neuropathy alone, but perceived stress did not differ.
Key findings
01Compared with survivors who reported only chemotherapy-induced neuropathy, those who also reported hearing loss and tinnitus had more trouble with balance and worse timed get up and go scores.
02The group with neuropathy, hearing loss, and tinnitus reported more pain interference and higher state anxiety and depressive symptoms than the neuropathy-only group.
03Generic quality of life scores were lower in the group with neuropathy, hearing loss, and tinnitus than in the neuropathy-only group, but perceived stress scores did not differ among the groups.
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What it does not show
The comparisons were made after treatment at the study visit, so they cannot show that hearing loss and tinnitus caused the worse symptoms or that they developed after chemotherapy. Hearing loss and tinnitus were classified from two self-report questions, not audiometric testing, and no pretreatment hearing assessment was done, so age, noise exposure, or other causes cannot be ruled out. Only survivors who had received platinum and/or taxane chemotherapy were included, and only four had head and neck cancer, so the findings may not apply to other chemotherapy drugs or head and neck survivors. The groups differed in age, income, comorbidities, and pain, so worse outcomes may not be due to hearing loss and tinnitus alone. Balance was assessed with self-report questions, the timed get up and go test, and the Fullerton Advanced Balance test, not detailed vestibular testing, so sensory and vestibular contributions cannot be separated.
Declared interests
The authors declared no conflicts of interest. No funding source is reported in the supplied text.
The easy way to misread this
Do not conclude that chemotherapy caused the hearing loss and tinnitus or that reducing these symptoms will improve balance, pain, mood, or quality of life. The study grouped survivors after treatment using two self-report questions, had no pretreatment hearing assessment, and did not test any intervention, so age, noise exposure, comorbidities, or other factors cannot be ruled out.