PTOTSurveyChild: care, health and development2026

Health Functioning Moderates the Association Between Chronic Conditions and Mental Illness in Childhood.

Shannon V Reaume, Joel A Dubin, Christopher M Perlman and 1 others

PMID 41906801

WHAT IT FOUND

Children with a chronic condition were more than twice as likely to have a mood disorder, but not other mental illnesses.

The link to anxiety, ADHD and any mental illness appeared only in children with better health functioning.

Key findings

01Children with at least one chronic condition had more than twice the odds of a mood disorder (odds ratio 2.25, 95% confidence interval 1.36 to 3.74), but the study found no association between chronic conditions and any mental illness overall, anxiety, behaviour disorders or ADHD.

02Health functioning changed that picture. Among children with better health functioning, those with a chronic condition were 29% more likely to have any mental illness (p < 0.01), 21% more likely to have an anxiety disorder (p < 0.05) and 21% more likely to have ADHD (p < 0.05); among children with poorer health functioning there was no association between chronic conditions and any of those outcomes.

03Higher health functioning was linked to lower odds of mental illness in every model (odds ratios 0.63 to 0.77), and children who had been in contact with mental health services had much higher odds (3.71 to 7.47).

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTs

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What it does not show

The survey was done at a single point in time, so it cannot show whether chronic conditions lead to mental illness, whether mental illness worsens health, or both. Mental illness was a parent-completed symptom checklist over the previous six months rather than a diagnostic assessment, and the children themselves were not the reporters. Data were collected before the COVID-19 pandemic, so the current burden of combined physical and mental health problems may be underestimated. Autism spectrum disorder and learning disabilities were not on the condition checklist, so this study says nothing about them. Children living on Indigenous reserves and in collective dwellings such as welfare or justice settings were excluded. The authors describe these as potentially high-risk groups and say the findings cannot be generalised to them. Only about half of the households approached took part, and children with higher health functioning were somewhat more likely to have missing mental illness data, which could affect the health functioning results. The authors state that their explanation for why the chronic condition link showed up only in children with better health functioning is speculative and would need longitudinal studies. The mediation analysis of family functioning was labelled exploratory and not part of the main question.

Declared interests

The first author received an Ontario Graduate Scholarship and a University of Waterloo President's Scholarship to support the manuscript. The senior author holds the Canada Research Chair in Youth Mental Health and is an Associate Editor for this journal. The authors declare no conflicts of interest.

The easy way to misread this

Do not read the moderation result as children with poorer health functioning being protected from mental illness. The authors suggest their mental health needs may be overshadowed by pressing physical health concerns, or that assessment is harder in this group and problems go under-reported. The survey was cross-sectional, so it cannot tell you which problem came first.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →