PTOTSLPOtherMolecular autism2021

Exploring sensory phenotypes in autism spectrum disorder.

Nichole E Scheerer, Kristina Curcin, Bobby Stojanoski and 6 others

PMID 34641960

WHAT IT FOUND

Parent reports grouped autistic participants into five sensory patterns.

The broad sensory difference group had lower daily living and social scores, while the most typical group had higher scores. IQ and sex did not differ across the groups.

Key findings

01A cluster analysis of 599 participants found five sensory phenotypes: sensory adaptive, generalized sensory differences, taste and smell sensitivity, under-responsive and sensory seeking, and movement difficulties with low energy.

02The five groups differed on age, adaptive behaviour, repetitive behaviours, social communication, ADHD traits, and OCD traits, but not on IQ or sex assigned at birth.

03The generalized sensory differences group had lower adaptive behaviour scores than the sensory adaptive group.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs

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What it does not show

The results are based on subjective parent or caregiver report measures, so they may not generalize to other informants or settings. The data came from existing records, and not all measures were completed for all participants. The sample included 17.2% with intellectual disability, while the paper notes an estimate of 33% in the autistic population, so autistic people with intellectual disability were underrepresented. The sensory questionnaire has limited evidence of convergent validity, so the sensory grouping depends heavily on this measure. The study is an exploratory grouping of existing records, so it cannot show that sensory phenotype causes behaviour differences or that intervention will work. The age range was wide, and many measures produced unstandardized scores, which complicates direct comparison across ages.

Declared interests

The paper lists funding from Canadian government, university, and research foundations, including the Government of Ontario, Western University, the Natural Sciences and Engineering Research Council of Canada, the Canadian Foundation for Innovation, the Ontario Brain Institute, and the Masonic Foundation of Ontario. It does not report a commercial sponsor or author conflict in the supplied text.

The easy way to misread this

Do not read these phenotypes as proof that a sensory intervention will improve behaviour. The study grouped parent-reported sensory scores and compared them with other parent-reported measures in existing records, so it does not test treatment effects.

Read it on PubMed →