PTOTPilotPhysical & occupational therapy in pediatrics2025

Exploring Posturography in Children with Sickle Cell Disease.

Victoria G Marchese, Emily McCarthy, Simon Ho and 2 others

PMID 40062602

WHAT IT FOUND

Children with sickle cell disease scored lower on clinical balance tests but showed no deficits in computerized posturography.

This suggests their balance problems are not caused by impaired sensory integration or weight-shifting strategies.

Key findings

01Children with sickle cell disease performed significantly poorer on the BOT-2 balance test compared to controls.

02There were no significant differences in composite scores for limits of stability or average postural sway on the mCTSIB between groups.

03Children with sickle cell disease demonstrated a more favorable vestibular ratio during static standing tasks compared to controls.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTs

Read the rest of this summary

You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.

Already have one?

What it does not show

The study was a pilot with a small sample size (14 per group) and was underpowered to detect differences in key parameters like vestibular ratio and BOT-2 scores. The assessor was not blinded to group status, which could introduce bias. Hemoglobin levels and fatigue were not recorded, so their potential impact on balance performance could not be analyzed. Posturography tasks were performed with feet stationary, which may not reflect challenges in dynamic activities with a moving base of support.

Declared interests

The text does not explicitly state funding sources or conflicts of interest in the provided sentences.

The easy way to misread this

Do not conclude that children with SCD have no balance impairments. They performed significantly worse on the clinical BOT-2 balance test. The null findings on posturography indicate that the *mechanism* of their balance deficit is likely not sensory integration or weight-shifting strategy, not that the deficit is absent.

Read it on PubMed →