"Taking Charge and Being Responsible": A Qualitative Study of Meaning Making and Motivations for Preexposure Prophylaxis Adherence Among Gay, Bisexual, and Other Sexual Minoritized Men Engaged in Alcohol Misuse in Kentucky.
Lesley M Harris, Blake D Skidmore, Nqobile Nzama and 8 others
PMID 40197987WHAT IT FOUND
Men taking PrEP while using alcohol described it as self-care, pride, routine, and peace of mind.
Alcohol mostly did not change dosing, but PrEP safety plus heavy drinking sometimes increased condomless sex.
Key findings
01Participants generally reported little to no effect of alcohol on PrEP adherence, but some delayed dosing and linked PrEP safety plus heavy drinking to condomless sex.
02Participants linked PrEP engagement to daily routine, mental well-being, proactive health management, community safety, and peace of mind.
03Affirming provider relationships and regular follow-up visits helped participants stay engaged with PrEP.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Only 10 patients were included, all self-identified male and mostly gay, so the findings are limited to this small group. All participants reported positive perceptions of PrEP, so people with negative perceptions or lower adherence were not represented. Follow-up interviews were conducted, but time intervals between data collection were short, so longer-term changes in alcohol use and adherence were not observed. The study took place in Kentucky PrEP care sites, so local access, stigma, and community norms may differ from other settings. This is a qualitative study, so it describes participants' experiences and cannot show that any routine, provider relationship, or counseling approach improves adherence.
The easy way to misread this
Do not read this as proof that PrEP routines, provider support, or peace of mind improve adherence. The study described 10 men's experiences; it did not test interventions or measure outcomes.