PTOTSLPOtherRehabilitation psychology2026

Self-regulation resource model of body compassion in multiple sclerosis.

Erin G Mistretta, Lindsey M Knowles, Jennifer K Altman and 2 others

PMID 40244955

WHAT IT FOUND

In 799 adults with multiple sclerosis, feeling compassionate toward one's own body was linked to higher confidence managing symptoms.

This confidence was associated with less drug use and better social participation, but not with exercise. These are cross-sectional links, not proof that compassion causes behavior change.

Key findings

01Body compassion was strongly associated with health self-efficacy (β = .752) and negatively associated with negative affect (β = −.903).

02Health self-efficacy partially mediated the link between body compassion and both drug use (β = −.193) and social participation (β = .463).

03Contrary to predictions, neither health self-efficacy, positive affect, nor negative affect was significantly associated with exercise.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs

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What it does not show

The study is cross-sectional, so it cannot prove that body compassion causes better health behaviors or that self-efficacy mediates the relationship; the variables could influence each other in different orders. All data were self-reported, raising the possibility that relationships are inflated by common-method variance. Missing data was substantial (8.2% to 25.2%), and sensitivity analyses showed that the lack of association between self-efficacy and exercise changed when different statistical methods were used. The exercise measure was self-developed and not validated. The alcohol screening tool (AUDIT-C) had poor reliability in this sample. Item parceling was used in the models, which can obscure the underlying structure of the data and reduce the ability to identify issues with individual items.

Declared interests

The paper does not report any funding sources or conflicts of interest.

The easy way to misread this

Do not assume that practicing body compassion will increase exercise levels in patients with multiple sclerosis. In this study, body compassion was not linked to exercise through the measured self-regulation resources, and the relationship between self-efficacy and exercise changed depending on how missing data was handled.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →