Muscle synergies demonstrate only minimal changes after treatment in cerebral palsy.
Benjamin R Shuman, Marije Goudriaan, Kaat Desloovere and 2 others
PMID 30925882WHAT IT FOUND
After injections, nerve surgery, or orthopedic surgery, plus usual rehabilitation, children's muscle coordination patterns changed little.
Small changes made the patterns less like typical walkers. Orthopedic surgery improved walking form, but walking speed decreased.
Key findings
01After treatment plus usual rehabilitation, the number of muscle patterns needed to explain the walking signal did not change significantly in any group.
02The variance explained by a single muscle pattern increased by 1.3% after botulinum toxin plus usual rehabilitation and by 1.9% after selective dorsal rhizotomy plus usual rehabilitation. The increase moved children away from typical patterns.
03Children whose muscle pattern activation became more similar to typical patterns had better gait form and walking speed after treatment plus usual rehabilitation.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
This was a retrospective analysis of clinical motion analysis data collected during usual care. The time before and after treatment varied. Usual rehabilitation, growth, and development were not separated from treatment effects. Some children used assistive devices or therapist support while walking, which can alter biomechanics and muscle activity. The electromyography analysis covered eight muscles, and some channels had poor or missing data. The number and quality of walking trials varied between children and sessions. Many outcomes were tested, and the selective dorsal rhizotomy speed change did not remain significant after multiple comparison correction. The study did not examine muscles not recorded during standard clinical gait analysis.
Declared interests
Funding came from MD-Paedigree, KU Leuven internal funding, the National Institute of Neurological Disorders and Stroke, the Washington Research Foundation, and the Dutch Organization for Scientific Research. The article gives no author conflict disclosures.
The easy way to misread this
Do not read the improved gait deviation index after single event multi level orthopedic surgery plus usual rehabilitation as evidence that the treatment made muscle coordination more typical. Synergy weights did not change, and the small changes in single synergy variance moved children away from typical patterns.