PTOTRCTEuropean journal of physical and rehabilitation medicine2025

High-frequency repetitive transcranial magnetic stimulation for stroke patients lower extremity function: primary motor cortex versus cerebellar stimulation. A randomized controlled trial.

Feng Lai, Xiang Liu, Fang Li and 3 others

PMID 41364023

WHAT IT FOUND

After stroke, two weeks of high-frequency brain stimulation to the motor cortex or cerebellum, with conventional rehab and medication, improved lower-limb function and balance more than sham.

The contribution of brain stimulation alone cannot be separated from the other treatments.

Key findings

01Two weeks of high-frequency rTMS to M1 or cerebellum, given with conventional medication and rehabilitation, improved lower-limb motor function more than sham, with no significant difference between M1 and cerebellar.

02The same active rTMS, added to conventional medication and rehabilitation, improved Berg Balance Scale scores more than sham, with no significant difference between M1 and cerebellar.

03Active rTMS plus conventional medication and rehabilitation also improved Modified Barthel Index scores more than sham, but the trial cannot separate the effect of rTMS from the other treatments.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTs

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What it does not show

The intervention lasted only two weeks, so it does not show whether gains persist or whether one stimulation site is better over time. All patients received conventional medication and conventional rehabilitation, so the contribution of rTMS alone cannot be separated. The blinding description is unclear: the paper says the therapist performing the magnetic maneuver was unaware of group, but also says the therapist stimulated different brain areas according to group. Four patients dropped out early, two from sham and two from cerebellar stimulation. The paper's prose and table report different between-group results for movement track length, so that secondary balance sway finding is unclear. The authors did not test the mechanism, so their explanations for cerebellar effects are not demonstrated by this trial.

Declared interests

The authors state there is no conflict of interest with any financial organization regarding the material discussed.

The easy way to misread this

Do not read the Discussion's claim that cerebellar stimulation is superior to motor cortex stimulation for balance as established. The Berg Balance Scale showed no significant difference between the two active groups; only a sway-length measure differed.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →