SLPCohortCoDAS2026

Hearing assessment of infants with congenital syphilis.

Pâmela da Silva Panassol, Luciana Friedrich, Leticia Petersen Schmidt Rosito and 2 others

PMID 42018804

WHAT IT FOUND

No hearing loss was found in infants treated for congenital syphilis.

Sixty-one of 65 passed newborn screening and none of the 23 seen at 3 months had abnormal brainstem responses. Most did not return for that check.

Key findings

01Of 65 infants treated for congenital syphilis, 61 (93.8%) passed both parts of newborn hearing screening and 4 (6.1%) failed both.

02None of the 23 children assessed at around 3 months showed abnormal brainstem responses: no difference between the ears, normal wave latencies and interpeak intervals, and normal hearing thresholds at the frequencies tested.

03Only 23 of the 65 infants (35.4%) returned for the 3-month assessment; the rest were never examined.

STILL TO COME

How it was doneWhat they foundWhat it means for SLPs

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What it does not show

Only 23 of the 65 infants were assessed at 3 months. The other two thirds were never examined, so a hearing problem in those children would not have been picked up. Follow-up stopped at about 3 months. Congenital syphilis can cause hearing loss that appears later, so this study could not have detected it. Every baby in the study was asymptomatic for congenital syphilis at birth. Nothing here tells you about babies who are symptomatic, and the authors found no studies of hearing in that group. Middle ear function was not measured objectively because the equipment was unavailable; the ear drum was checked by eye with an otoscope, so a middle ear problem could have been missed. There was no comparison group. The study describes what was found in these infants rather than how they compare with infants without congenital syphilis. One centre, small numbers, and the authors themselves call for larger studies with longer follow-up.

Declared interests

The paper declares no financial support and nothing to declare for conflicts of interest. No other funding, sponsor involvement or author disclosure is reported.

The easy way to misread this

Do not read this as proof that congenital syphilis leaves hearing intact. Only 23 of the 65 infants were assessed at 3 months and no child was followed beyond that, while the paper itself notes that hearing loss can appear later, around two years of age.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →