Factors influencing the prognosis of patients with acute cerebral infarction who received usual care: a multicenter prospective cohort study.

The timing of final evaluation was not uniform between groups, with the Poor Outcome Group staying in the hospital significantly longer (30.45 days vs 21.63 days), which may have influenced functional scores at discharge. The study did not assess higher brain dysfunction or cognitive function, which are known predictors of functional outcomes. Rehabilitation intensity was measured only by the number of sessions, not by the content or quality of the exercises performed. Patients who mobilized within 48 hours were excluded, so findings do not apply to early mobilization protocols. Subtentorial lesions and patients with pre-onset dependence (mRS ≥3) were excluded, limiting generalizability to more complex or severe cases.

The work was supported by JSPS KAKENHI Grant Number 21K17499. The authors declared no conflicts of interest.

Do not interpret the lack of significance for mobilization timing as evidence that early mobilization is ineffective overall. This study only looked at patients who were already mobilized late (≥48 hours); it cannot speak to the effects of mobilizing within the first 48 hours.