Excellent Recanalization and Small Core Volumes Are Associated With Favorable AM-PAC Score in Patients With Acute Ischemic Stroke Secondary to Large Vessel Occlusion.
Vivek Yedavalli, Manisha Koneru, Meisam Hoseinyazdi and 17 others
PMID 38163017WHAT IT FOUND
In acute large-vessel stroke, smaller core volumes, younger age, milder initial stroke, and excellent vessel reopening were associated with favorable discharge AM-PAC mobility and daily-activity scores.
This is an association from records, not proof of treatment effect.
Key findings
01Of 229 patients, 79 had favorable AM-PAC scores and 150 had unfavorable AM-PAC scores.
02Favorable AM-PAC was independently associated with younger age, lower admission NIHSS, mTICI recanalization score, and lower rCBF <30% volume.
03Excellent recanalization, mTICI 2C/3, had an odds ratio of 3.06 for favorable AM-PAC compared with mTICI 0/1/2A/2B.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTs
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What it does not show
The study looked at past records, so it could show associations but not prove that smaller core volumes or excellent recanalization caused favorable AM-PAC scores. CT perfusion was required, and the authors note it is not widely available in smaller and rural centers, limiting generalizability. The time frame included patients who received IV tPA rather than newer thrombolysis such as IV tenecteplase. The recanalization analysis used mTICI data from 181 patients, while the overall sample was 229. The authors say prospective studies are needed to validate the findings.
The easy way to misread this
Do not read these findings as proof that smaller core volumes or excellent recanalization caused better AM-PAC scores. The study looked at past records and reported associations.