PTSLPSystematic ReviewJournal of autism and developmental disorders2026

Examining Behavioral Interventions for Infancy and Early Toddlerhood: A Systematic Review of Intervention Effects, Parameters, and Participants.

Jessica J Simacek, Amy Riegelman, Jaclyn Gunderson and 4 others

PMID 40325287

WHAT IT FOUND

Across 69 infant studies, contingent caregiver responses to baby sounds increased vocalizations in first-year studies.

Tummy-time studies increased head lifting. Evidence was heterogeneous, and some randomized trials showed no effect.

Key findings

01In first-year vocalization studies, caregivers who imitated or matched infant sounds contingently increased infant vocalization rates.

02Four first-year tummy-time studies targeting head elevation reported increased head elevation with intervention.

03In second-year communication studies, three randomized trials reported positive effects and four reported nonsignificant or null effects.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for SLPs

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What it does not show

The analysis reported effects descriptively across single-case, quasi-experimental, and randomized studies, so the evidence is hard to compare. Many studies used short-term or proximal outcomes, such as frequency of vocalizations, and follow-up was not always collected or did not always persist. Intervention duration and dose were often unclear or incompletely reported, so the review cannot identify how much intervention was needed. Demographic information was missing for most participants: infant race was reported for 23% of infants, ethnicity for 13%, and parent race was not reported for 90% of participants. The samples were largely white and Western, with 84% of studies having author affiliations in the United States, so generalizability to other communities is limited. Some randomized trials showed no effect on communication outcomes, so positive findings from single-case and quasi-experimental studies need cautious interpretation. Many interventions included caregiver training, coaching, and routine embedding together, so the effect of any single component cannot be separated. The review protocol was developed before searching but was not preregistered.

Declared interests

The funding section names the National Institute of Mental Health and Neurosciences and the University of Minnesota College of Education and Human Development. No author conflict-of-interest declarations are provided in the supplied text.

The easy way to misread this

Do not conclude that these behavioral interventions are proven treatments for any infant communication or motor delay. The review reported effects descriptively across heterogeneous experimental, single-case, and quasi-experimental studies, many outcomes were proximal, dosage was often unclear, and some randomized trials showed no effect.

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