PTSLPCohortDevelopmental medicine and child neurology2023

Early detection of developmental delay in infants born very preterm or with very low birthweight.

Rebecca A Caesar, Roslyn N Boyd, Giovanni Cioni and 5 others

PMID 37017185

WHAT IT FOUND

Fidgety movements at 16 weeks corrected age that were not continuous, plus abnormal writhing movements at 4 to 5 weeks corrected age, flagged later motor and cognitive delay at 24 months in very preterm infants; no assessment flagged language delay.

Key findings

01Fidgety movements at 16 weeks corrected age that were not continuous were strongly associated with developmental delay at 24 months corrected age.

02Combining abnormal writhing general movements at 4 to 5 weeks corrected age with fidgety movements at 16 weeks corrected age that were not continuous was the best model for predicting developmental delay.

03No clinical assessment used in this study predicted language delay at 24 months corrected age, but untreated otitis media was associated with expressive language delay.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for SLPs

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What it does not show

The final analysis included 79 children, and only five had developmental delay, so estimates of diagnostic accuracy had wide confidence intervals. Twenty-four percent were lost to follow-up at 24 months corrected age, although the paper reports no major differences between those who remained and those lost. Families had to speak English and live within 100 kilometres of a hospital, and infants with major congenital or chromosomal abnormalities were excluded, so results may not apply to all very preterm infants. The Bayley-III may not accurately identify infants at risk of developmental delay, and it was the only measure used for cognitive delay, so some cognitive deficits may have been missed. The proposed movement trajectory classification was derived from these data and has not been tested in an independent sample. The study was observational, so it shows associations between early movement patterns and later delay, not that any treatment based on these assessments improves outcomes.

Declared interests

Funding was provided by the Allied Health Professions' Office of Queensland Health Practitioner Grant Scheme, the National Health and Medical Research Council, and Wishlist Sunshine Coast Hospital Foundation. The supplied text does not include an author conflict-of-interest statement.

The easy way to misread this

Do not conclude that non-continuous fidgety movements at 16 weeks corrected age mean a child has developmental delay. The study found an association, not a diagnosis, and only five of 79 children had developmental delay, with wide confidence intervals.

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