Development of Neural Response to Novel Sounds in Fragile X Syndrome: Potential Biomarkers.
Lauren Ethridge, Andrew Thaliath, Jeremy Kraff and 2 others
PMID 33211818WHAT IT FOUND
Brain responses to novel sounds differed between individuals with Fragile X Syndrome and controls, with higher gamma power in the FXS group.
Gamma power correlated with sensory avoidance and sensitivity in males, suggesting it is a reliable marker for clinical trials.
Key findings
01Individuals with FXS showed larger N1 and P2 amplitudes and higher gamma power compared to controls.
02In males with FXS, higher gamma power was associated with lower scores for sensory avoidance and sensitivity.
03Most ERP measures, including P1, N1, and gamma power, demonstrated strong test-retest reliability over one month.
STILL TO COME
How it was doneWhat they foundWhat it means for OTsWhat it means for SLPs
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What it does not show
The sample size for test-retest reliability was small (14 participants) and limited to younger individuals, so reliability in adults is unknown. The study is cross-sectional, so it cannot track individual developmental trajectories over time. Correlations between gamma power and sensory measures were only significant in males, possibly due to small sample sizes for gender-separated analyses.
The easy way to misread this
Do not interpret the correlation between gamma power and sensory scores as evidence that reducing gamma power will improve sensory symptoms. The study is observational and shows an association, not a causal mechanism.