OTRCTJournal of developmental and behavioral pediatrics : JDBP2023

Depressive Symptoms in Autistic Youth with Anxiety Disorders.

Rebecca L Greenberg, Andrew G Guzick, Sophie C Schneider and 4 others

PMID 38019467

WHAT IT FOUND

42.7% of autistic 7-13 year-olds with anxiety reported clinically elevated depressive symptoms, while only 20.2% of parents reported the same.

Depression did not predict how well anxiety-focused CBT worked in this secondary analysis of a trial.

Key findings

0135 of 82 autistic children (42.7%) rated their own depressive symptoms at or above the clinical cutoff, while 17 of 84 parents (20.2%) rated their child's symptoms that high.

02After adjusting for the other variables, child-reported anxiety and loneliness were the only features uniquely linked to children's own reports of depressive symptoms, and parent-reported anxiety and functional impairment the only ones uniquely linked to parent reports. Autism severity was related to depressive symptoms on its own but fell out once other factors were accounted for.

03Depressive symptoms at baseline did not predict anxiety severity after treatment or at the three-month follow-up, on either child or parent report.

STILL TO COME

How it was doneWhat they foundWhat it means for OTs

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What it does not show

There was no comparison group of typically developing children, so the study cannot show whether these rates of depressive symptoms are higher than in non-autistic children of the same age. Only 87 children were eligible for treatment, and a quarter of the anxiety scores were missing after treatment and a third at three months, mostly because of dropout during COVID-19. Recruitment happened during the pandemic, when school closures may have raised isolation, loneliness and anxiety above usual levels, so the rates may not match your caseload. Participants were mostly white, 78% male, and parent reports came mainly from mothers with university education, so the findings may not generalise to other families. Most of the analyses were cross-sectional, so the study cannot say whether anxiety and loneliness cause depressive symptoms or the other way round. Children had to have an IQ of 70 or above and be able to communicate verbally, so this says nothing about non-speaking autistic children or those with a significant intellectual disability. Depression was measured with a parent and child questionnaire cutoff, not a diagnostic interview, and this analysis did not compare the two CBT conditions.

Declared interests

The supplied article text contains no funding or conflict of interest statement. It notes only that the original trial was approved by the college's Institutional Review Board.

The easy way to misread this

Do not turn the 42.7% into a diagnosis of depression in autistic children. Depressive symptoms here were measured with a 13-item screening questionnaire and a cutoff score rather than a diagnostic interview, and the children were recruited during the COVID-19 pandemic when isolation and anxiety were unusually high, so the figure may not hold in your clinic.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →