Childhood Predictors of Young Adult Social Functioning in 22q11.2 Deletion Syndrome.
Kayla E Wagner, Wendy R Kates, Wanda Fremont and 1 others
PMID 28527096WHAT IT FOUND
Parents reported lower social functioning in young adults with 22q11.2DS than in control peers, but self-reported social functioning did not differ.
Childhood internalizing symptoms predicted lower parent-reported social functioning later, while general intelligence and executive skills did not.
Key findings
01Parents reported significantly lower social functioning in young adults with 22q11.2DS than in siblings and community controls, and the group difference remained after controlling for full-scale IQ.
02Self-reported social and leisure functioning did not differ significantly across the 22q11.2DS, sibling and community control groups.
03In the 22q11.2DS group, childhood internalizing symptoms predicted lower parent-reported young adult social functioning, while childhood general intelligence and executive functioning did not.
STILL TO COME
How it was doneWhat they foundWhat it means for OTs
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What it does not show
Parent and self reports of social functioning disagreed, and the study did not use direct observation or peer-based social measures. Previous social skills training, psychotherapy, medication or other treatments were not accounted for. The sibling and community control groups were small and not adequately powered for those comparisons. The analysis did not adjust for multiple comparisons, so some findings may be chance associations. Control participants were not genetically screened, and the design cannot show that childhood symptoms caused later social difficulty.
Declared interests
The authors declared no conflicts of interest. The supplied text does not state who funded the work.
The easy way to misread this
Do not read these predictors as proof that treating childhood internalizing symptoms will improve social functioning. The study was observational, parent and self reports disagreed, and no intervention was tested.