PTOTSLPOtherRehabilitation psychology2026

Associations among epilepsy phenotypes and pain, sleep interference, and dissociative symptoms.

Jack D Watson, Elise V Bailey, Amy Henion and 5 others

PMID 41712343

WHAT IT FOUND

How much epilepsy interferes with daily life predicted pain, sleep, and dissociative symptoms more strongly than specific comorbidity profiles.

Veterans with polytrauma or chronic disease phenotypes reported higher pain, while those with polytrauma or bipolar/SUD reported more sleep interference.

Key findings

01Epilepsy interference was the strongest predictor of pain, sleep, and dissociative symptoms, explaining more variance than any specific comorbidity phenotype.

02After controlling for covariates, PTSD, polytrauma, and chronic disease phenotypes remained significantly associated with pain interference.

03After controlling for covariates, polytrauma and bipolar/SUD phenotypes remained significant predictors of sleep interference, but no phenotype predicted dissociative symptoms.

STILL TO COME

How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs

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What it does not show

The sample was predominantly non-Hispanic White and had a higher proportion of women than the general veteran population, which may limit generalizability. Results may not apply to younger or older veterans, or to civilians with epilepsy, as the sample was exclusively middle-aged veterans. Comorbidity phenotypes were derived from electronic health record codes, which capture the presence of conditions but not their severity. Sleep interference was measured with a single, unvalidated item rather than a full scale, and the study relied entirely on self-report without symptom validity checks.

Declared interests

Data access is managed through the Department of Veterans Affairs; no specific funding sources or author conflicts of interest are detailed in the provided text.

The easy way to misread this

Do not assume that specific comorbidity clusters (like PTSD or anxiety) are the primary drivers of dissociative symptoms in this population. The study found that once covariates were controlled, no epilepsy phenotype predicted dissociative symptoms; instead, the general interference of epilepsy with daily life was the sole significant predictor.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →