Adherence to pharmacological treatment after hematopoietic stem cell transplantation: context analysis.
Larissa Beatriz Francisca de Souza, Katiane Domingos Soares, Allyne Fortes Vitor and 3 others
PMID 41337527WHAT IT FOUND
After stem cell transplant, medication adherence at home was shaped by distress, side effects, forgetfulness, complex regimens, family support, and clear discharge teaching.
The review mapped these factors but did not show which intervention improves adherence.
Key findings
01Adherence to medication after hospital discharge for stem cell transplant patients was shaped by interrelated contexts: patient factors, home management, professional-patient relationship, and institutional guidelines.
02Psychological distress, including depression, stress, social isolation, tension, anguish, and denial of treatment, was the most frequently reported patient factor interfering with adherence.
03The review identified practical supports such as medication organizers, reminders, educational materials, pharmacist follow-up, and family support. It did not establish which component caused better adherence.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The review maps contexts rather than testing whether any intervention improves adherence. The authors note scarce intervention studies. This limits understanding of impact of specific contexts. Subjective and self-report adherence measures were common. Reported adherence may depend on what patients report.
Declared interests
No conflicts of interest or funding were stated in the supplied text.
The easy way to misread this
Do not read the mapped supports as proven ways to improve adherence. This was a scoping review of contexts, not a trial or effectiveness synthesis.