TOPIC

Neurological research

Everything we have read on neurological. Each paper is summarised from the full article rather than its abstract, so the limitations are in there too, and the funding wherever the paper declares it.

3,875 PAPERS · PAGE 49 OF 78 · NEWEST FIRST

• PTOTCohort2024Comparison of Upper Extremity Function and Daily Use in Individuals with and without Post Stroke Depression.Neurorehabilitation and neural repairDepression did not affect arm function during early rehabilitation but was linked to significantly worse arm use and independence at six months. Clinicians should monitor mood closely when patients transition home, as depression may hinder the carryover of therapy gains to daily life.
• PTOTOther2023Spatial mapping of posture-dependent resistance to passive displacement of the hypertonic arm post-stroke.Journal of neuroengineering and rehabilitationPost-stroke arm stiffness is not uniform. It depends heavily on where the hand is in space, with strong forces pulling toward a central equilibrium and less resistance in the middle of the workspace. This pattern is driven by muscle activity, not just tight tissues.
• PTOTOther2023Reduced physical activity level was associated with poorer quality of life during the early phase of the COVID-19 pandemic: a sub-study of the last-long trial.Journal of rehabilitation medicineStroke survivors who reported less physical activity during lockdown were significantly more likely to report poorer quality of life. This association remained after adjusting for loneliness, mental health, and social activity. No participants reported improved activity or quality of life.
• PTOTOther2023The impact of lesion side on bilateral upper limb coordination after stroke.Journal of neuroengineering and rehabilitationRight hemisphere stroke made alternating two-hand circles harder to coordinate. Left hemisphere stroke made simultaneous circles harder, especially the weaker hand's path. This pattern could help choose two-hand practice.
• PTQualitative2023A Brain Computer Interface Neuromodulatory Device for Stroke Rehabilitation: Iterative User-Centered Design Approach.JMIR rehabilitation and assistive technologiesStroke survivors and physiotherapists viewed the brain-computer interface device as a useful tool, not a therapist substitute. They valued its ability to increase rehabilitation intensity but flagged the headset's poor social acceptability and complex setup as major barriers to home use.
• PTOther2023Audiovisual biofeedback amplifies plantarflexor adaptation during walking among children with cerebral palsy.Journal of neuroengineering and rehabilitationChildren and adolescents with cerebral palsy increased calf muscle activity during treadmill walking with every biofeedback type. Audiovisual feedback, alone or with an exoskeleton, held the gain longest. Combined feedback was faster than audiovisual feedback, not larger. The gain stopped when feedback stopped.
• PTOTQualitative2023Delivery of a community-based peer mentorship program for people with spinal cord injury at a rehabilitation center.Frontiers in rehabilitation sciencesPeer mentors were on site with a rehab team that included PTs and OTs. Patients sometimes confused mentors with clinicians. Shared workspace, informal talks, and a written agreement on boundaries were described as important for collaboration.
• PTOTSLPCohort2024Perceived stress and pain interference in acute rehabilitation following spinal cord injury: Resilience as a moderator.Rehabilitation psychologyDuring acute spinal cord injury rehab, high resilience did not stop stress from worsening pain intensity. But for patients with low resilience, every point of stress increased pain interference. Screening for resilience may help identify those most vulnerable to stress-related disability.
• PTOTOther2024Effects of enriched task-specific training on sit-to-stand tasks in individuals with chronic stroke.NeuroRehabilitationAfter a three-week package of task-specific exercise, socialization, and sensory and cognitive stimulation, 41 people with chronic stroke averaged 2.1 more 30-second chair stands, still present at six months. There was no control group. Weight-bearing changes were inconsistent in three participants.
• PTOTOther2024The impact of a novel musculoskeletal consult service in an inpatient rehabilitation facility: A descriptive analysis.PM & R : the journal of injury, function, and rehabilitationInpatients with refractory musculoskeletal pain saw significant pain reduction after sports medicine consults, especially those receiving injections. Functional improvement was greater in patients who did not need injections, suggesting those treated with procedures had more severe underlying impairments.
• PTOTSLPCohort2024The association of multiple sclerosis, traumatic brain injury, and spinal cord injury to acute and long COVID-19 outcomes.PM & R : the journal of injury, function, and rehabilitationPatients with MS, TBI, or SCI had no higher risk of death or longer stays than matched controls, but those with SCI were hospitalized more often. Across all three groups, MS and TBI patients showed higher odds of post-COVID weakness, mobility issues, and cognitive dysfunction.
• PTOTCohort2024Reduced oxygen desaturation in the vastus lateralis of chronic stroke survivors during graded muscle contractions.Topics in stroke rehabilitationStroke survivors show reduced oxygen use in both legs compared to healthy controls. The non-paretic leg also has impaired oxygen handling, even when strength is normal. This suggests muscle physiology changes affect the whole body, not just the weak side.
• PTOTQualitative2023Competing discourses as barriers to change in rehabilitation nursing: a discourse analysis.Frontiers in rehabilitation sciencesNurses in a spinal cord injury unit described patient dialogue as central to participation, but tight task routines left little time. The analysis found a dominant biomedical task culture that blocked time for dialogue.
• PTOTSLPCohort2023Traumatic Brain Injury Rehabilitation Outcome Prediction Using Machine Learning Methods.Archives of rehabilitation research and clinical translationModels using therapy records and patient factors predicted TBI discharge and 9-month outcomes. Effort during OT, PT and speech therapy, age, injury severity and time to rehab were strongest clues. They do not show which treatment caused recovery.
• PTOTCohort2023Excellent Recanalization and Small Core Volumes Are Associated With Favorable AM-PAC Score in Patients With Acute Ischemic Stroke Secondary to Large Vessel Occlusion.Archives of rehabilitation research and clinical translationIn acute large-vessel stroke, smaller core volumes, younger age, milder initial stroke, and excellent vessel reopening were associated with favorable discharge AM-PAC mobility and daily-activity scores. This is an association from records, not proof of treatment effect.
• PTOTOther2023Quality of sexual life in Mexican men after spinal cord injury.Journal of rehabilitation medicineMexican men with thoracic spinal cord injuries reported significantly lower sexual life quality than those with lumbar injuries. Higher education levels were also linked to greater sexual satisfaction. These findings highlight specific risk factors for sexual dysfunction in this population.
• PTCohort2023Body-weight support gait training in neurological intensive care: safety, feasibility, and delays before walking with or without suspension.Journal of neuroengineering and rehabilitationIn a neurological ICU, 78 suspended walking sessions on 33 brain-injury patients were tolerated with transient interruptions only. Suspension could support walking when patients were too weak to stand, but staffing and device barriers stopped 45 eligible patients.
• PTOTRCT2024Effects of anodal tDCS on resting state eeg power and motor function in acute stroke: a randomized controlled trial.Journal of neuroengineering and rehabilitationAdding anodal tDCS to physical therapy improved lower-limb function in acute stroke patients with mild impairment, but did not improve upper-limb function or change brain activity compared to sham. The benefit was seen immediately and lasted one month.
• PTOTSLPNarrative Review2024Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repairPost-stroke fatigue likely has distinct subtypes with different biological drivers, meaning a single treatment rarely works for everyone. Inflammation, dopamine pathways, and sensory network dysfunction are key suspects, but current evidence is too limited to recommend specific interventions beyond general exercise and careful assessment.
• PTOTRCT2024Effects of an assist-as-needed equipped Tenodesis-Induced-Grip Exoskeleton Robot (TIGER) on upper limb function in patients with chronic stroke.Journal of neuroengineering and rehabilitationAssist-as-needed TIGER robot training plus task-specific motor training improved Fugl-Meyer scores from baseline in 16 chronic stroke patients, but the original constant-assistance TIGER showed greater gains, so the new mode was not superior.
• PTPilot2024Potential Effects of an Exoskeleton-Assisted Overground Walking Program for Individuals With Spinal Cord Injury Who Uses a Wheelchair on Imaging and Serum Markers of Bone Strength: Pre-Post Study.JMIR rehabilitation and assistive technologiesA 16-week exoskeleton walking program showed mixed bone results in 10 people with spinal cord injury. Femoral neck bone mineral content increased, but femoral cortical thickness decreased. No control group was used, so these changes cannot be confirmed as treatment effects.
• PTOTSLPNarrative Review2024A review of combined functional neuroimaging and motion capture for motor rehabilitation.Journal of neuroengineering and rehabilitationCombining motion capture with brain imaging shows promise for assessing movement, but the field is in its infancy. Most studies are small, use healthy participants, and lack clinical validation, so there is no evidence yet that this changes patient outcomes.
• PTOther2023The Functional Balance Ability Measure: A Measure of Balance Across the Spectrum of Functional Mobility in Persons Post-Stroke.Archives of rehabilitation research and clinical translationCombining Berg and Functional Gait items into one 100-point score appeared to measure a single balance ability from sitting to walking in 93 ambulatory people post-stroke. It separated them into distinct balance levels, but only community-dwelling adults were studied.
• PTOTOther2023Prediction of Discharge Destination After Inpatient Rehabilitation for Stroke Using Mobility and Self-Care Assessment in Section GG of the Inpatient Rehabilitation Facility - Patient Assessment Instrument.Archives of rehabilitation research and clinical translationFor stroke patients leaving inpatient rehab, having a caregiver at home was the strongest predictor of going home rather than to a skilled nursing facility. Admission Section GG scores above 33.5 predicted discharge to home with homecare, and scores above 36.5 predicted home with outpatient therapy.
• PTPilot2023The Effect on Muscle Activity of Reaching Beyond Arm's Length on a Mobile Seat: A Pilot Study for Trunk Control Training for People After Stroke.Archives of rehabilitation research and clinical translationOn a mobile seat, people after stroke generally had lower multifidus and external oblique activity during reaching, while healthy participants generally had higher multifidus activity. Erector spinae did not differ.
• PTOTSLPCohort2023Effect of Post-stroke Depression on Functional Outcomes of Patients With Stroke in the Rehabilitation Ward: A Retrospective Cohort Study.Archives of rehabilitation research and clinical translationStroke patients with depression had lower functional independence scores at discharge and stayed in rehabilitation longer. However, their total improvement in independence during the stay was similar to patients without depression. Depression slowed recovery speed but did not stop progress.
• PTOTSLPQualitative2023Managing Fatigue: Experiences From a 6-week Course for Adults With Cerebral Palsy.Archives of rehabilitation research and clinical translationEight adults with cerebral palsy found a fatigue course helpful for understanding their condition and connecting with peers. However, they struggled to implement the strategies because the homework was confusing and the information overload increased their fatigue.
• PTPilot2023Characteristics of Gait Event and Muscle Activation Parameters of the Lower Limb on the Affected Side in Patients With Hemiplegia After Stroke: A Pilot Study.Archives of rehabilitation research and clinical translationAfter stroke, the affected leg had longer swing time and shorter stance phase. Only medial gastrocnemius median power frequency differed; most muscle measures did not.
• PTOTOther2023Range of Motion Limitations in Middle-aged Adults With Cerebral Palsy.Archives of rehabilitation research and clinical translationMiddle-aged adults with cerebral palsy have widespread joint mobility limitations, especially in the hips and shoulders. These restrictions are more severe in those with higher GMFCS levels and dyskinetic CP, but do not worsen with age in this group.
• PTOTSLPOther2023Developing and Evaluating Data Infrastructure and Implementation Tools to Support Cardiometabolic Disease Indicator Data Collection.Topics in spinal cord injury rehabilitationMost inpatients did not recall being taught about aerobic exercise or having their lipids checked, and fewer than half of outpatients met activity guidelines. An AI tool extracted survey data with less than 1% error, but this quality improvement project reports no evidence that the interventions changed outcomes.
• PTOTSLPCohort2024Change characteristics of health-related quality of life and its association with post-stroke fatigue at four-year follow-up.Journal of rehabilitation medicineMost stroke survivors had stable high function at four-year follow-up, but fatigue clustered in trajectories with poorer or worsening quality of life. Some improved, and some deteriorated, between the first and fourth year.
• PTOTOther2024Social participation, resilience, and coping tendency in a sample of stroke survivors: a multi-centre cross-sectional study in China.Journal of rehabilitation medicineStroke survivors with higher resilience reported better social participation. For those with low resilience, using positive coping strategies was linked to less frequent participation, not more. Assess resilience before targeting coping skills.
• PTOTQualitative2023Providing Insights into the Challenges of Implementing Activity-Based Therapy in Canada: A Comparative Analysis Using Focus Group Interviews with Key Interest Groups.Topics in spinal cord injury rehabilitationClinicians, patients, and administrators in Canada identified six barriers to activity-based therapy for spinal cord injury: gaps in training, lack of standardization, unclear timing, difficulty achieving high dosage, funding constraints, and poor measurement tools.
• PTOTCase Series2023Combinatorial Effects of Transcutaneous Spinal Stimulation and Task-Specific Training to Enhance Hand Motor Output after Paralysis.Topics in spinal cord injury rehabilitationCombining hand grip training with transcutaneous spinal stimulation improved grip strength in six people with spinal cord injury or stroke. Neither training nor stimulation alone worked well. This preliminary evidence suggests the combination is necessary for gains.
• PTQualitative2023Communicating Standing and Walking Data after Spinal Cord Injury: A Patient-Engaged, Qualitative Study.Topics in spinal cord injury rehabilitationPeople with spinal cord injury want feedback on their walking, but preferences vary widely. Most wanted a mix of verbal and written updates to track progress. Some found scores less useful than noting real functional gains. A personalized feedback plan agreed upon at admission may better meet these individual needs.
• PTCase Series2023The Orthotic Effects of Different Functional Electrical Stimulation Protocols on Walking Performance in Individuals with Incomplete Spinal Cord Injury: A Case Series.Topics in spinal cord injury rehabilitationElectrical stimulation during walking immediately improved toe clearance in people with incomplete spinal cord injury. Stride length and speed changed differently depending on baseline walking ability.
• PTOTSLPOther2023What Is the Pathway to the Best Model of Care for Traumatic Spinal Cord Injury? Evidence-Based Guidance.Topics in spinal cord injury rehabilitationA new care pathway for traumatic spinal cord injury maps the full journey from acute trauma to lifelong community living. It prioritizes team-based navigation, equity, and peer support, giving clinicians a structured model to coordinate transitions and reduce service gaps.
• PTOTPilot2023Using Risk Scores to Estimate Lower Extremity Fragility Fracture Risk among Individuals with Chronic Spinal Cord Injury: A Preliminary Model.Topics in spinal cord injury rehabilitationA preliminary risk score using five clinical factors estimates 5-year lower extremity fracture risk in chronic spinal cord injury. Prior fracture and duration of injury drive the score. The model is not validated for clinical use due to small sample size.
• PTOTQualitative2023Designing an Egocentric Video-Based Dashboard to Report Hand Performance Measures for Outpatient Rehabilitation of Cervical Spinal Cord Injury.Topics in spinal cord injury rehabilitationTherapists prioritized seeing video clips and movement quality to judge home hand use, while physicians preferred numerical trends. All seven clinicians wanted summarized data to save appointment time and requested patient diaries to understand barriers like pain or frustration.
• PTOTPilot2024Decoding hand and wrist movement intention from chronic stroke survivors with hemiparesis using a user-friendly, wearable EMG-based neural interface.Journal of neuroengineering and rehabilitationA wearable EMG sleeve decoded 12 hand and wrist movements in seven chronic stroke survivors with 77.1% accuracy. Decoding worked best when visible movement was present. For severe impairments, binary intent detection achieved 86.7% accuracy, though no physical therapy outcome was tested.
• PTOTSLPSystematic Review2024Use of the Capability, Opportunity and Motivation Behaviour model (COM-B) to Understand Interventions to Support Physical Activity Behaviour in People with Stroke: An Overview of Reviews.Clinical rehabilitationInterventions combining at least two COM-B elements (capability, opportunity, motivation) improved physical activity after stroke, while single-element interventions often failed. Most evidence involved adults with mild stroke in community settings, leaving gaps for those with severe disability.
• PTOTSLPOther2024Which information derived from the Coma Recovery Scale-Revised provides the most reliable prediction of clinical diagnosis and recovery of consciousness? A comparative study using machine learning techniques.European journal of physical and rehabilitation medicineFor patients with prolonged disorders of consciousness, the detailed scores from each subscale of the CRS-R predicted recovery of consciousness and diagnosis at discharge more reliably than the overall CRS-R total score or the initial clinical diagnosis alone. Use subscale profiles for prognostication.
• PTRCT2024Myoelectric interface for neurorehabilitation conditioning to reduce abnormal leg co-activation after stroke: a pilot study.Journal of neuroengineering and rehabilitationChronic stroke survivors walked 0.15 m/s faster after MINT conditioning, exceeding the 0.1 m/s minimum clinically important difference. No adverse events were reported, but there was no control group.
• PTOTSLPCohort2024Utility of Structured Oculomotor, Balance, and Exercise Testing in Civilian Adults With Mild Traumatic Brain Injury.American journal of physical medicine & rehabilitationEye tracking and exercise tests found physical deficits in most adults with mild brain injury, even when patients reported few symptoms. These objective measures reveal problems that questionnaires miss, suggesting clinicians should not rely on patient reports alone to guide treatment.
• PTOTSLPCohort2024Rehabilitation with intensive attention training early after acquired brain injury promotes better long-term status on health-related quality of life, daily activities, work ability and return to work.Journal of rehabilitation medicinePatients starting intensive attention training within 4 months of brain injury had better long-term quality of life, work ability, and return-to-work rates than those starting later. The specific type of training made little difference overall, though early process-based training showed minor advantages.
• PTOTSLPOther2024Criteria and Indicators for Centers of Clinical Excellence in Stroke Recovery and Rehabilitation: A Global Consensus Facilitated by ISRRA.Neurorehabilitation and neural repairSeven consensus criteria for stroke rehabilitation centers were agreed, led by outstanding rehabilitation, then research culture, patient partnership, knowledge exchange, leadership, education, and equitable access.
• PTOTSLPSystematic Review2024Upper limb intention tremor assessment: opportunities and challenges in wearable technology.Journal of neuroengineering and rehabilitationWearable sensors and smartphone tasks can quantify upper limb tremor, but intention tremor remains hard to measure accurately. Current tools often fail to separate the tremor from the voluntary movement, requiring new algorithms and tasks designed specifically for goal-directed actions.
• PTOTSLPCohort2024Individualized goals expressed by patients undergoing stroke rehabilitation: an observational study.Journal of rehabilitation medicineStroke patients prioritized walking and daily tasks, but few set goals for cognitive or visual deficits despite having them. Patient-specific goal measures capture functional activities well but may miss underlying impairments, so clinicians should ask about these areas directly rather than relying on scores.
• PTOTMeta-Analysis2024Association between fear of falling and falls following acute and chronic stroke: a systematic review with meta-analysis.Journal of rehabilitation medicinePeople with acute stroke who answer yes to "are you afraid of falling?" have a higher risk of falls. In chronic stroke, a simple yes/no question misses the link, so use a confidence scale like the FES or ABC to spot the risk.
• PTOTCohort2023Comparison of usefulness between the Mini-Balance Evaluation Systems Test and the Berg Balance Scale for measuring balance in patients with subacute stroke: a prospective cohort study.Frontiers in rehabilitation sciencesThe Mini-BESTest detects balance changes during subacute stroke rehab better than the Berg Balance Scale. The Berg scores hit a ceiling for 43% of patients at discharge, hiding further improvement. The Mini-BESTest avoided this, making it more useful for tracking progress in higher-functioning patients.