TOPIC

Neurological research

Everything we have read on neurological. Each paper is summarised from the full article rather than its abstract, so the limitations are in there too, and the funding wherever the paper declares it.

3,875 PAPERS · PAGE 46 OF 78 · NEWEST FIRST

• PTOTSLPCohort2023Neural coding of autonomic functions in different states of consciousness.Journal of neuroengineering and rehabilitationBrain-heart signal coupling was higher in patients with lower consciousness levels. This pattern helps distinguish unresponsive or minimally responsive patients from those who have emerged, offering a non-invasive, bedside tool to support behavioral assessments.
• PTOTCohort2023Balance assessment in selected stages of Parkinson's disease using trend change analysis.Journal of neuroengineering and rehabilitationA new balance metric called the Trend Change Index (TCI) successfully distinguished Parkinson's patients from healthy controls in both early and later stages. Unlike standard speed measurements, this metric detected balance differences in Stage II patients who otherwise looked normal on traditional tests.
• PTOther2023Validity of functional assessment for control of trunk in patients with subacute stroke: a multicenter, cross-sectional study.Journal of physical therapy scienceThe FACT trunk assessment takes about 3.5 minutes to administer, significantly less time than the Trunk Impairment Scale. It correlates strongly with trunk control and walking independence, offering a valid, feasible tool for physical therapists to assess subacute stroke patients.
• PTOTRCT2023Efficacy of integrating a semi-immersive virtual device in the HABIT-ILE intervention for children with unilateral cerebral palsy: a non-inferiority randomized controlled trial.Journal of neuroengineering and rehabilitationReplacing half the hands-on therapy time in a HABIT-ILE camp with a virtual screen device improved hand function and daily life skills just as well as usual therapy. It did not improve walking, so keep lower-limb practice physical.
• PTOTSLPOther2023Utilization of overground exoskeleton gait training during inpatient rehabilitation: a descriptive analysis.Journal of neuroengineering and rehabilitationPatients with stroke, spinal cord injury, and traumatic brain injury tolerated progressively longer and more independent walking in overground exoskeletons during inpatient rehabilitation. Therapists used specific clinical milestones to decide when to start, challenge, and stop the device, but no control group proves this approach improves outcomes.
• PTOTSLPQualitative2023Exploring community reintegration among Nigerian stroke survivors.The South African journal of physiotherapyTwelve Nigerian stroke survivors described how mobility and communication barriers stopped them working, cooking or socialising. Those who returned to roles relied on family support and a positive mindset. This reports their lived experience, not evidence that any specific intervention improves reintegration.
• PTOTSLPNarrative Review2023EARLY CONSIDERATIONS OF GENETICS IN APHASIA REHABILITATION: A NARRATIVE REVIEW.AphasiologyGenetic factors like BDNF and APOE may influence how well patients recover language after a stroke. This review suggests these genes could help match patients to specific therapies, such as brain stimulation, but no genetic testing is currently used in routine clinical care.
• PTCohort2023Effects of individualized lower limb isokinetic strengthening in clinical rehabilitation of older post-stroke patients: A retrospective study.Journal of rehabilitation medicineIn older subacute stroke patients, adding individualized knee strengthening to physiotherapy and occupational therapy was associated with larger gains in independence and mobility. The study was not randomised, so this is a possible benefit, not proof.
• PTOther2023The effect of paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component on heart rate and heart rate variability in healthy subjects.Frontiers in rehabilitation sciencesHigh-intensity paired associative stimulation did not cause lasting cardiovascular stress in 17 healthy adults. Heart rate variability changes during the session were transient and likely caused by sitting still rather than the stimulation itself. The protocol appears safe for further development.
• PTOTSLPCohort2023Predicting institutionalization after Subacute Stroke Rehabilitation using the 12-Item World Health Organization Disability Assessment Schedule.Journal of rehabilitation medicineA 12-item disability questionnaire completed by caregivers at discharge accurately predicted which stroke patients would need institutional care. Scores above 27.7 indicated a high likelihood of institutionalization. Participation limitations were as predictive as daily activity limitations, suggesting discharge planning should weigh social engagement heavily.
• PTOTRCT2023Robotic arm training in neurorehabilitation enhanced by augmented reality - a usability and feasibility study.Journal of neuroengineering and rehabilitationA prototype robot arm plus HoloLens game was safe and usable in patients with upper limb weakness, but patients rated reliability lower than established arm robots.
• PTPilot2023Combining spinal neuromodulation and activity based neurorehabilitation therapy improves sensorimotor function in cerebral palsy.Frontiers in rehabilitation sciencesSix children with cerebral palsy showed greater motor function gains after eight weeks of spinal neuromodulation combined with therapy than after sham neuromodulation with therapy. Gains persisted ten weeks later. This tiny study cannot separate the device's contribution from the activity-based therapy.
• PTOTPilot2023Reliability, Validity and Minimal Detectable Change of a Power Leg Press Test in Individuals with Cerebral Palsy.Physical & occupational therapy in pediatricsA modified leg press test reliably measures leg power in children and adults with cerebral palsy. To detect true change, average peak power must improve by more than 10.7% in adults or 19% in children. This test takes 15 minutes and costs about $6,500.
• PTOTCohort2023Impairments of the ipsilesional upper-extremity in the first 6-months post-stroke.Journal of neuroengineering and rehabilitationRobot testing found significant arm impairment in nearly half of stroke survivors one week after stroke. By six months, this dropped to 14%. Standard clinical scales missed many of these deficits, identifying only 16% of patients as impaired. Side of brain injury did not affect impairment severity.
• PTOTSLPCase Report2023Anodal Contralesional tDCS Enhances CST Excitability Bilaterally in an Adolescent with Hemiparetic Cerebral Palsy: A Brief Report.Developmental neurorehabilitationIn one adolescent with cerebral palsy, anodal tDCS to the contralesional hemisphere increased corticospinal tract excitability bilaterally for 30 minutes. This neurophysiologic change was not seen with sham stimulation. Clinical motor outcomes were not measured.
• PTOther2023The development of a flexion range-of-motion-adjustable knee joint for knee-ankle-foot orthoses and evaluation of gait in healthy individuals wearing it.Journal of physical therapy scienceA new adjustable knee joint for orthoses allowed controlled flexion during walking. In healthy adults, the 15° and 30° settings increased knee bending in early stance compared to a fixed joint, while the free setting allowed the largest bend in late stance.
• PTOTRCT2023sEMG-controlled forearm bracelet and serious game-based rehabilitation for training manual dexterity in people with multiple sclerosis: a randomised controlled trial.Journal of neuroengineering and rehabilitationFor people with MS, adding MYO Armband games to conventional physical therapy did not improve the main gross manual dexterity outcome. Some wrist motion and grip strength differences appeared, but the Armband's separate effect cannot be separated.
• PTOTSLPQualitative2023Family Perspectives on In-Home Multimodal Longitudinal Data Collection for Children Who Function Across the Developmental Spectrum.Journal of developmental and behavioral pediatrics : JDBPFamilies want in-home data collection to be flexible, pausable during medical crises, and to include siblings. They value receiving their own data to understand their child's invisible symptoms. This feedback shapes how to design accessible research for complex needs.
• PTOTSLPRCT2023Effect of very early supported discharge versus usual care on activi-ties of daily living ability after mild stroke: a randomized controlled trial.Journal of rehabilitation medicineVery early supported discharge sped up recovery of complex daily tasks like shopping and transport. By three months, home-based teams helped patients with mild stroke do these tasks better than usual care, but the groups were equal by one year.
• PTOTSLPQualitative2023Goal-setting and personalization under the International Classification of Functioning, Disability, and Health framework: Community reintegration program for post-stroke patients.Frontiers in rehabilitation sciencesPost-stroke patients shifted from setting vague goals like 'walking better' to specific, environment-based goals like 'using the subway' after goal-setting with therapists. This suggests that prompting patients to describe their real-life contexts early in rehab helps them define more meaningful and achievable targets for community reintegration.
• PTOTSLPCohort2023Aphasia improvement without logotherapy during motor neurorehabilitation of post-stroke hemiparesis using virtual reality or modified constraint-induced movement therapy: A retrospective cohort.NeuroRehabilitationSevere post-stroke aphasia improved in all three motor rehab groups without speech therapy. Virtual reality yielded the highest language scores and satisfaction. The contribution of each component cannot be separated from general motor training.
• PTOTMeta-Analysis2023Shoulder ultrasound imaging in the post-stroke population: a systematic review and meta-analysis.Journal of rehabilitation medicineUltrasound scans of hemiplegic shoulders in post-stroke patients frequently show damage to the biceps tendon (41.4%) and supraspinatus tendon (33.2%). These structural issues are significantly more common on the affected side than the unaffected side, but motor function severity did not predict the presence of these lesions.
• PTOTOther2023Quality of Physical Activity Participation Among Adults with Disabilities Through Pandemic Restriction.Canadian journal of occupational therapy. Revue canadienne d'ergotherapieAdults with disabilities described losing independence and motivation during pandemic restrictions. They adapted by using home exercises and online classes, but relied heavily on social support. No baseline factor predicted later quality of activity, so clinicians cannot assume one variable drives participation.
• PTQualitative2023What matters to program partners when implementing a community-based exercise program for people post-stroke? A theory-based qualitative study and cost analysis.Frontiers in rehabilitation sciencesManagers chose stroke exercise programs based on reputation and cost, while instructors felt nervous without prior experience with mobility issues. Healthcare partners helped staff gain confidence, but clear roles and funding were needed to sustain the program.
• PTOther2022A technical report on a novel robotic lower limb rehabilitation device - Is ROBERT® a cost-effective solution for rehabilitation in Hong Kong?Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liaoThis report estimates that a Danish lower-limb robot costs less per hour to run than a physiotherapist. It assumes the robot replicates the therapist's movement exactly, so it claims no clinical benefit or patient outcome improvement.
• PTOTOther2023Telehealth Delivery of Evidence-Based Intervention Within Older Adult Populations: A Scoping Review.OTJR : occupation, participation and healthTelehealth delivery of evidence-based occupational therapy for older adults is feasible and often preferred by clients, but it does not consistently outperform in-person care. Success depends on adapting activities for the screen and ensuring clients have reliable technology access and support.
• PTOTSystematic Review2023Structural and pathophysiological muscle changes up to one year after post-stroke hemiplegia: a systematic review.European journal of physical and rehabilitation medicineMuscle loss and electrical changes start within hours of stroke on the affected side, but also occur on the unaffected side. Early rehab should target both limbs to prevent atrophy and maintain strength.
• PTOTSLPQualitative2023Feasibility and Acceptability of a Codesigned Health Care Transition Intervention for Young People With Spinal Cord Injuries.Topics in spinal cord injury rehabilitationYoung people with spinal cord injury and clinicians found a new transition website easy to use and helpful for preparing for adult care. They said it works best when a therapist introduces it in clinic, rather than expecting families to find it alone.
• PTPilot2023A 3-minute recumbent stepper test in chronic stroke.PM & R : the journal of injury, function, and rehabilitationIn 15 people with chronic stroke, a 3-minute all-out recumbent stepper test after a graded exercise test raised peak heart rate more than the recumbent stepper graded test alone. It did not outperform treadmill testing, and its screening value is not proven.
• PTPilot2023Medial Gastrocnemius Muscle Properties of Children With Cerebral Palsy After Different Tone Treatments: A Pilot Study.American journal of physical medicine & rehabilitationChildren with cerebral palsy had different gastrocnemius biopsy features after botulinum toxin, selective dorsal rhizotomy, or minimal tone treatment. With one participant per group, the study cannot show what each treatment did to muscle.
• PTCohort2024Determinants of Frame Running Capacity in Athletes With Cerebral Palsy to Improve Training Routines and Classification Strategies: A Cross-sectional Observational Study.American journal of physical medicine & rehabilitationSpasticity in hip and knee extensors, along with thigh muscle thickness, were the strongest predictors of frame running distance in athletes with cerebral palsy. These physical traits explained 75% of the variance in performance, offering specific targets for training and classification.
• PTSurvey2023Soothe the savage beast: Patient perceptions of the benefits of music therapy in an inpatient rehabilitation facility.PM & R : the journal of injury, function, and rehabilitationPatients in inpatient rehab were mostly neutral about music therapy, not resistant. Favorable and neutral responses covered 79.8% of the sample. Younger and more educated patients were more receptive, and better knowledge was related to more positive attitudes.
• PTOTSLPPilot2023Feasibility of performing a multi-arm clinical trial examining the novel combination of repetitive transcranial magnetic stimulation and aerobic exercise for post-stroke depression.Topics in stroke rehabilitationCombining brain stimulation and treadmill walking is feasible for post-stroke depression, with high adherence and mild side effects. Preliminary data suggest both interventions reduce symptoms, but the study is too small to prove which treatment works or if the combination is superior to either alone.
• PTPilot2023Factors influencing neuromuscular responses to gait training with a robotic ankle exoskeleton in cerebral palsy.Assistive technology : the official journal of RESNAIn eight children with cerebral palsy, walking kinematics influenced soleus muscle response to a robotic ankle exoskeleton more than device resistance or practice. A more extended leg posture during stance increased muscle activation. This pilot suggests monitoring for compensatory crouch gait is critical.
• PTOTQualitative2023Developing a community-engaged wheelchair exercise program for persons with MS: community advisory board formation and feedback.Disability and rehabilitation. Assistive technologyWheelchair users with MS advised that exercise programs must offer flexible aerobic bouts, alternative resistance options like wrist weights, and clear guidance on handling setbacks. They emphasized independence in equipment setup and requested coaching by clinicians or peers to support adherence.
• PTOther2023Predictors of non-stepping time in people with chronic stroke.Topics in stroke rehabilitationIn 280 adults with chronic stroke, lower walking endurance, assistive device use, more depressive symptoms and higher BMI were linked to more non-stepping time. Programs to break up non-stepping time may need to address these factors, not just cognition or balance confidence.
• PTOTOther2023Engaging in a home-based exercise program: a mixed-methods approach to identify motivators and barriers for individuals with stroke.Assistive technology : the official journal of RESNAStroke survivors engaged with a home exercise app but rarely met the recommended dose. They were motivated by activities that felt useful and by seeing their own progress. Caregiver availability and daily schedules were the main barriers. Tailoring the program to the person and their support network is essential.
• PTOTCohort2023Enhanced Street Crossing Features are Associated with Higher Post-Stroke Physical Quality of Life.Topics in stroke rehabilitationLiving near street crossings with better features (like curb cuts) was associated with higher physical quality of life after stroke. Sidewalk quality and nearby destinations showed no such link. This suggests accessible crossings are a specific environmental target for post-stroke recovery.
• PTOTOther2023Corpus Callosal Microstructure Predicts Bimanual Motor Performance in Chronic Stroke Survivors: a Preliminary Cross-Sectional Study.Topics in stroke rehabilitationIn chronic stroke survivors, poorer corpus callosum fiber organization was linked to slower bimanual task performance among those who used both hands, not among those who used one hand.
• PTOTSLPCohort2022A Network Analysis of the PART-O at 1 and 2 Years After TBI: A Veterans Affairs Model Systems Study.The Journal of head trauma rehabilitationSocial relationships and internet use were the most central parts of participation for veterans with TBI. Seeing friends and providing emotional support became more strongly linked over time, suggesting these social interactions deepened during recovery.
• PTOTSystematic Review2024A systematic review and cross-sectional survey of rehabilitation resources for injury patients in the Kilimanjaro Region of Tanzania.Disability and rehabilitationEight rehabilitation organizations were identified in Tanzania’s Kilimanjaro region. Most require out-of-pocket payment, which limits access for patients without insurance. Awareness of these services is low among both patients and referring doctors.
• PTOTCase Report2024A big data approach to evaluate receipt of optimal care in childhood cerebral palsy.Disability and rehabilitationA new scoring method measured how closely two children's cerebral palsy care matched best-practice guidelines. Both children had low adjusted scores, primarily because they did not see physical, occupational, and rehabilitation specialists together in most years.
• PTOTQualitative2024Requirements for home-based upper extremity rehabilitation using wearable motion sensors for stroke patients: a user-centred approach.Disability and rehabilitation. Assistive technologyFor sub-acute stroke home rehab, patients and therapists prioritised real-time feedback, personalised goals, weekly therapist contact, and easy independent use.
• PTCohort2023The Impact of Blast Exposure-With or Without Traumatic Brain Injury-on Metabolic Abnormalities in Post-9/11 Veterans.The Journal of head trauma rehabilitationBlast exposure, close blast exposure within 10 meters, or blast-related TBI were not associated with abnormal waist-hip ratio, waist circumference, glucose, or metabolic syndrome in 734 post-9/11 Veterans.
• PTOTSLPCohort2023Differences in Risk of Alzheimer's Disease Following Later-Life Traumatic Brain Injury in Veteran and Civilian Populations.The Journal of head trauma rehabilitationTraumatic brain injury after age 68 strongly increased the risk of Alzheimer's diagnosis, but this risk dropped significantly with each passing year. The elevated danger appeared to fade roughly five years after the injury, suggesting the link is short-term rather than permanent.
• PTOTCohort2023Does Spasticity Correlate With Motor Impairment in the Upper and Lower Limbs in Ambulatory Chronic Stroke Survivors?American journal of physical medicine & rehabilitationIn ambulatory chronic stroke survivors, upper limb spasticity correlated with greater motor impairment and weaker grip strength. Lower limb spasticity did not correlate with motor impairment or gait speed. Clinicians may need to prioritize weakness over spasticity when addressing lower limb walking function.
• PTOTRCT2024Associations between baseline cognitive status and motor outcomes after treadmill training in people with Parkinson's disease: a pilot study.Disability and rehabilitationPeople with Parkinson's and mild cognitive impairment improved their gait speed as much as those with normal cognition after treadmill training. However, better memory scores at the start predicted larger speed gains. Motor severity also mattered: lower baseline symptoms linked to greater improvement.
• PTOTSLPOther2023Clinical practice recommendations for management of lateropulsion after stroke determined by a Delphi expert panel.Clinical rehabilitationExperts agreed on 119 recommendations for lateropulsion care, prioritising tactile cues and active self-correction over passive correction. They rejected routine use of novel tech like VR. No consensus was reached on optimal therapy dose, leaving that to clinical judgement.
• PTOTSLPPilot2023Promoting Resilience After Stroke in Dyads (ReStoreD): A Supplemental Analysis.Archives of physical medicine and rehabilitationResilience scores improved significantly in people with stroke after a 8-week dyadic activity programme. Care partners showed no significant change. The waitlist control group dropped out, so the analysis was single-arm and cannot confirm the programme caused the improvement.
• PTCohort2023Using the Instrumented Sway System (ISway) to Identify and Compare Balance Domain Deficits in People With Multiple Sclerosis.Archives of physical medicine and rehabilitationPeople with MS had larger and faster standing sway than controls. Those with MS who had fallen also had larger and faster sway than those who had not. Other sway patterns did not differ. It does not prove sway causes falls.