Toward personalizing prosthesis prescription: A take-home study of three microprocessor-controlled prosthetic knees: A randomized crossover study.

Small sample size (10 participants) limits generalizability. No washout period between knee trials may have introduced carryover effects. The cohort was highly experienced and predominantly used Otto Bock (C-Leg) or Össur (Rheo) devices clinically, potentially biasing patient-reported outcomes toward familiarity. No participant had prior experience with the Power Knee, which may have affected their ability to use it effectively during the short one-week trial. One week of use may be insufficient to fully adapt to major technology changes, such as switching from passive to active control.

Funded by the Department of Defense Congressionally Directed Medical Research Program. Manufacturers provided knees and training at no cost but were not involved in funding, design, or data interpretation. The EPIC lab receives separate funding from Össur for unrelated projects.

Do not interpret the lack of statistical significance in secondary measures like falls or step count as evidence that the knees are functionally identical in daily life. The study was underpowered for these outcomes, and individual variability was high, meaning a patient might still experience a meaningful difference in community function that this group-level analysis did not capture.