The Relationship Between Baseline Volume in Temporal Areas and Post-Treatment Naming Accuracy in Primary Progressive Aphasia.

The study included only 21 people with PPA, and only 10 had remediation items, so the findings may not apply to every subtype or to people with different baseline naming patterns. The authors did not analyse each PPA subtype separately because there were too few participants in each group for that analysis. The volume analysis focused only on regions that were already smaller than controls, so other temporal areas that may affect naming were not fully tested. The study did not measure whether brain volume changed during the treatment period or whether change predicted treatment response. The pattern differed across exemplar sets, and testing order may have influenced post-treatment retrieval practice, so the untrained-item correlations are not straightforward.

Do not conclude that baseline temporal lobe volume predicts naming improvement after treatment. The significant correlations were for untrained items, not for treated items, and the study had too few participants to separate PPA subtypes.