The Prevalence of Infection and Sepsis Associated Dysphagia in Hospitalised Patients: A Retrospective Cross-sectional Study.
Ayodele Sasegbon, Karim Bastawisy, Ivy Cheng and 1 others
PMID 41779180WHAT IT FOUND
Sepsis and infection were associated with new-onset dysphagia in hospitalised patients.
Sepsis carried a higher risk than infection alone. Older patients and those with dementia, delirium or Parkinson's disease were most likely to develop swallowing difficulties during admission.
Key findings
01Sepsis was associated with a significantly increased risk of developing dysphagia during hospital admission, with an odds ratio of 1.74.
02Patients with infections who developed dysphagia were significantly older, frailer, had longer hospital stays and higher mortality than those who did not.
03Parkinson's disease, dementia and delirium were also strong independent risk factors for new-onset dysphagia in this population.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs
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What it does not show
The study relied on ICD-10 clinical coding data, which is not perfectly accurate and may have missed cases of subtle dysphagia or miscoded oesophageal dysphagia as oropharyngeal. The retrospective design prevents establishing causality; it is unclear whether the infection/sepsis caused the dysphagia or if pre-existing subclinical dysphagia was unmasked. No baseline instrumental swallowing assessments were performed at admission, so the timing of onset and recovery dynamics could not be determined. The study did not follow up patients post-discharge, so the persistence of dysphagia after leaving hospital is unknown. Residual confounding remains a possibility, as unmeasured factors (e.g., severity of illness, medication effects) may have influenced the results.
Declared interests
The authors declared no competing interests.
The easy way to misread this
Do not assume that infection or sepsis directly causes dysphagia in all cases. The study identifies an association, but because it was retrospective and lacked baseline swallowing assessments, it cannot rule out that the dysphagia was pre-existing but subclinical and simply became apparent during the stress of illness.
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