The Management of Critically Colonized and Locally Infected Leg Ulcers with an Acid-Oxidizing Solution: A Pilot Study.

This was a single-arm pilot case series with 30 patients and no control or comparison group, so improvements cannot be compared with standard care. All patients received the acid-oxidizing solution with Adaptic and Vliwazell dressings, and patients with venous ulcers also received compression therapy, so the contribution of any single component cannot be separated. The study was open-label and assessed by a single investigator, which can affect infection scoring, pain reporting and wound measurements. No swabs or microbiologic analyses were performed, so bacterial load and organism type were not measured. When wounds healed, later visits stopped and several parameters were missing, so the full course of infection, pain and bioburden is incomplete. Wounds were limited to up to 20 x 10 cm and excluded wounds with more than 60% necrotic eschar, so results may not apply to those patients.

Do not conclude that the acid-oxidizing solution alone caused the improvements or is proven better than standard care. This was an uncontrolled pilot case series, and all wounds received the solution with Adaptic and Vliwazell dressings, while venous ulcers also received compression therapy, so the contribution of any single component cannot be separated.