PTRCTJournal of neuroengineering and rehabilitation2025

The effects of combining anodal transcranial direct current stimulation with robot-assisted gait training on lower limb motor function and the motor cortex regulation of stroke patients.

Yujia Zhang, Yuqian Zhang, Beisi Zheng and 8 others

PMID 41163056

WHAT IT FOUND

Stroke patients on a 34-point lower limb motor scale improved more when anodal tDCS was added to robot-assisted gait training plus standard drug and rehabilitation care: 8.16 points on average versus 4.21 points with robot training plus standard care.

No sham stimulation was used.

Key findings

01The mean FMA-LE increase was 8.16 points in the tDCS plus robot-assisted gait training group and 4.21 points in the robot-assisted gait training group.

02The tDCS plus robot-assisted gait training group's post-treatment FMA-LE score was significantly higher than the robot group's, and the paper reports the combined group's improvement as clinically significant while the robot group's was not.

03Resting-state connectivity between left M1 and right PMC/SMA increased significantly only in the combined group.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

Single-centre randomised trial with a small sample size, so the result may not generalise. No sham tDCS control was used, so placebo or expectation effects cannot be ruled out. The supplied text does not report participant or therapist blinding. Both groups received robot-assisted gait training, conventional drug treatment and conventional rehabilitation, so the contribution of any single component cannot be separated. The paper reports only four-week outcomes and no long-term follow-up. The supplied text does not name the primary outcome. Participant counts are inconsistent: 43 were randomised, five were excluded, forty patients are described in the baseline section, two withdrew, and thirty-eight completed. Lesion location was not accounted for in the analysis.

The easy way to misread this

Do not conclude that anodal tDCS alone caused the improvement. Both groups received robot-assisted gait training, conventional drug treatment and conventional rehabilitation, and the experimental group also received anodal tDCS. There was no sham tDCS control, so the contribution of tDCS cannot be separated from placebo or from the other therapies.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →