The AVPR1A Gene and Its Single Nucleotide Polymorphism rs10877969: A Literature Review of Associations with Health Conditions and Pain.
Keesha L Roach, Patricia E Hershberger, Julienne N Rutherford and 3 others
PMID 29503216WHAT IT FOUND
AVPR1A variants, including rs10877969, were reported in limited studies as linked to pain, social behavior, and sickle cell disease, but the evidence is too limited to guide patient care.
Key findings
01After screening and exclusions, 24 articles remained for final synthesis.
02A three-way interaction among AVPR1A genotype, sex, and acute stress was reported in pain studies in mice and humans.
03AVPR1A and COMT were associated with flexion and range-of-motion deficits, while AVPR1A was associated with internal rotation and abduction deficits.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
This is a review of 24 articles, not a new patient study, so it cannot establish that AVPR1A causes pain differences. Ten studies included humans, nine included animals, three included both, and two used cDNA, so many findings are not direct human clinical evidence. Ethnicity was reported in only four human studies, so associations may not generalize across populations. Only one included citation addressed AVPR1A and sickle cell disease. The search was limited to 2009 to present and English; the authors note non-English studies may provide additional insight.
Declared interests
The supplied text does not include a funding or conflict-of-interest declaration, but the article is tagged as supported by N.I.H. extramural and non-U.S. government research.
The easy way to misread this
Do not read this as evidence that testing AVPR1A rs10877969 or related COMT variants can guide pain or range-of-motion care. The review found associations from limited human and animal studies, and only one included article addressed sickle cell disease.