Stability of vancomycin hydrochloride employed in antimicrobial seal solutions of central intravenous catheters.
Daniele Porto Barros, Priscilla Sete de Carvalho Onofre, Fernando Luiz Affonso Fonseca and 3 others
PMID 35920542WHAT IT FOUND
Vancomycin-heparin seal solutions formed precipitate at three hours at both temperatures.
The authors recommend not using this combination in central catheter seals.
Key findings
01The vancomycin-heparin solution formed precipitate at three hours, regardless of temperature.
02At 22°C, the vancomycin-heparin solution showed a drop of around 5% in antimicrobial concentration over time.
03At 37°C, the vancomycin-heparin solution started below the expected 5 mg/mL concentration immediately after preparation.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
No patients, families or actual central catheters were studied. The solutions were tested in glass vials, not in the material of central catheters. Only one vancomycin concentration, 5 mg/mL, and one heparin sodium concentration, 100 IU/mL, were tested. The study measured chemical stability and pH, not clinical outcomes such as infection, occlusion or embolism.
Declared interests
The supplied text reports funding from CNPq, grants 311296/2013-0 and 462183/2014-9. It does not state author conflicts of interest.
The easy way to misread this
Do not read this as proof that the combination caused harm in patients. It tested prepared solutions in glass vials, not people or catheters.