Speech-Language Disorders in 22q11.2 Deletion Syndrome: Best Practices for Diagnosis and Management.
Cynthia B Solot, Debbie Sell, Anne Mayne and 4 others
PMID 31330115WHAT IT FOUND
Children with 22qDS often have persistent language delay, speech sound disorders, velopharyngeal dysfunction, feeding and hearing problems.
Speech-language pathologists should assess early, use tailored therapy, and coordinate long-term team care.
Key findings
01Most children with 22qDS have significant receptive and expressive language impairments.
02Velopharyngeal dysfunction and submucous cleft palate are seen in 67% of children with 22qDS.
03Evidence-based intervention studies are limited, and many therapy procedures are based on evidence-based approaches used with similar disabilities without 22qDS.
STILL TO COME
How it was doneWhat they foundWhat it means for SLPs
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What it does not show
The article is a narrative review, not a systematic review, and it does not state how the cited studies were selected. It reports no original methods or results, so its recommendations are based on existing literature and expert opinion. There are few evidence-based studies of therapeutic interventions for children with 22qDS. The syndrome is highly variable, so the recommendations may not apply to every patient. Data on adults with 22qDS are limited, so long-term communication changes are uncertain.
Declared interests
The article reports support from National Institute of Mental Health and National Institutes of Health grants. No author conflict-of-interest declaration is given in the supplied text.
The easy way to misread this
Do not treat these recommendations as proven treatment outcomes. The review states that there are few evidence-based studies of therapeutic interventions for children with 22qDS.