RNCase ReportJournal of human lactation : official journal of International Lactation Consultant Association2024

Prolonged Jaundice in a Premature Breastfed Infant With Gilbert's Syndrome.

Frances Strobl, Melissa Ann Theurich

PMID 38334089

WHAT IT FOUND

Prolonged jaundice in a late preterm breastfed infant was confirmed as Gilbert's syndrome after genetic testing.

Visible jaundice resolved by 4 months, and at 6 months the infant was breastfeeding without formula.

Key findings

01Genetic testing confirmed Gilbert's syndrome, with UGT1A1*28 homozygous genotype.

02Visual signs of jaundice completely resolved by 4 months of age, and at 6 months the infant was breastfeeding without infant formula supplementation.

03The mother had a history of Gilbert's syndrome, and a possible family history led to referral to a pediatric gastroenterologist for prolonged jaundice and suspected Gilbert's syndrome.

STILL TO COME

How it was doneWhat they foundWhat it means for RNs

Read the rest of this summary

You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.

Already have one?

What it does not show

The report describes a single infant, so it cannot show whether any treatment worked or whether the outcome would be the same in other infants. The infant had late prematurity, feeding difficulty, suspected unresolved ankyloglossia, formula supplementation, frenectomy, osteopathic consultation, and specialist referrals, so the contribution of any one part of care cannot be separated. The mother had Gilbert's syndrome and a possible family history, which may have influenced referral and interpretation. Iron supplementation was recommended but not given early, and slight iron deficiency anemia was found later, so feeding and supplementation decisions were complex.

Declared interests

One author had previously received consultancy fees from UNICEF, WHO, LMU Munich, and the German Society for Paediatric and Adolescent Medicine, and had received travel fees from the Austrian Society for Paediatric and Adolescent Medicine. The authors received no financial support for the research, authorship, or publication.

The easy way to misread this

Do not read the infant's resolution as proof that any single feeding change, formula supplement, or frenectomy caused it. This report describes a single infant with several supports over time, and Gilbert's syndrome alone does not require secondary care referral or cause severe hyperbilirubinemia.

Read it on PubMed →