PTOtherJournal of neuroengineering and rehabilitation2026

Predicting prosthesis use and mobility needs in lower limb amputees: a machine learning approach using clinical and actigraphy data.

Sara Nataletti, Shusuke Okita, Jacob Sindorf and 10 others

PMID 41957611

WHAT IT FOUND

In 53 lower-limb amputees, models did not reliably predict reassessed K-level, but predicted personal mobility goals, including from 3 days of prosthesis-worn activity data.

Key findings

01Models predicting expert-reassessed K-level were limited, with recall from 0.30 to 0.60; the best model reached 0.60 using all feature sets with 30 days of actigraphy.

02Models predicting personal mobility goal attainment were better, reaching 0.89 with all feature sets and 30 days of actigraphy, 0.89 with performance-based outcomes alone, and 0.82 with 3 days of actigraphy only.

03Prescribed K-level matched the expert-reassessed K-level for 79% of participants, while AMP-based classification matched for 51%.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

Only 53 participants were analysed, and 46 had prescribed K3, so the models may not represent K2 or K4 users. Validation was internal, testing on participants from the same sample rather than a new clinic, so real-world performance may be optimistic. The expert panel's reassessed K-level and goal decisions involved clinical judgment, and the weight given to each data source was not fixed. ActiGraph data did not capture terrain, environmental barriers, or reasons for not wearing the prosthesis. Attrition occurred before or early in monitoring, mainly because of in-person visit burden in the parent trial, so completers may differ from those who dropped out. Seasonal variation in activity may have affected model performance across different monitoring lengths.

Declared interests

The supplied text names the U.S. Department of Defense as the funder. It does not state author conflicts of interest or whether the funder designed the study.

The easy way to misread this

Do not conclude that wearable actigraphy can replace clinical K-level assessment. The models predicting reassessed K-level were weak, with recall only 0.30 to 0.60, and the study did not test whether using these models improves patient outcomes.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →