Plasma Leptin and Reduced FEV1 and FVC in Chronic Spinal Cord Injury.
Eric Garshick, Palak Walia, Rebekah L Goldstein and 4 others
PMID 28827209WHAT IT FOUND
In chronic spinal cord injury, higher plasma leptin was linked to lower FEV1 and FVC, even after accounting for BMI and injury severity.
Adiponectin showed no association.
Key findings
01Increasing leptin was associated with decreasing FEV1 and FVC.
02The leptin association remained after adjustment for BMI, smoking, injury level and severity, mobility and other covariates.
03Adiponectin was not associated with FEV1, FVC or the FEV1/FVC ratio.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
The study is cross-sectional, so it measured leptin and lung function at one time and cannot show which came first. Participants had to travel to VA Boston and perform acceptable spirometry, so people with the most severe injury or poorest lung function may have been left out. The analysis used 285 of the 360 recruited participants after exclusions. 83% of participants were male and 91% were white, which limits how well the results apply to other groups with spinal cord injury. 2% of participants had only one acceptable spirometry effort, 27 used self-reported height, and some used self-reported weight.
Declared interests
The supplied text does not report author conflicts of interest. The publication types list NIH and U.S. Gov't, Non-P.H.S. research support.
The easy way to misread this
Do not conclude that leptin causes reduced FEV1 or FVC, or that lowering leptin would improve FEV1 or FVC. The study measured leptin and lung function at one time point in 285 participants, so it cannot show cause or effect.