Oxygen-Sensing Biomaterial Construct for Clinical Monitoring of Wound Healing.
Daniel Naveed Tavakol, Samantha C Schwager, Lindsay A Jeffries and 6 others
PMID 32701253WHAT IT FOUND
In mice and a pig, a thin oxygen-sensing film mapped wound oxygen and could be removed without leaving detectable nanoparticle signal, unlike liquid nanoparticles.
It has not been tested in people, so it does not change wound care yet.
Key findings
01The film's average relative oxygen signal was 0.85 ± 0.06, compared with 0.89 ± 0.04 for the liquid.
02After removal, film-treated wounds had an average signal of 0.99 ± 0.02, while liquid-treated wounds had 0.92 ± 0.02.
03Over 3 days, the film detected a 19% rise in relative wound oxygen signal, and the wounds closed by 65%.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The film was tested only in lab dishes, mice, and one pig, not in people with wounds. Mouse experiments used small groups: n = 3, n = 4, and n = 5. The pig comparison with transcutaneous probes showed only a slight correlation, with R2 = 0.44. The signal values are relative oxygen measures and have not been calibrated to actual oxygen levels. The wounds studied were acute surgical wounds, not chronic diabetic foot ulcers.
The easy way to misread this
Do not read this as a wound-care tool for patients. The film was tested only in the laboratory and in animals, and no human outcomes were measured.