Occupational engagement, fatigue, and upper and lower extremity abilities in persons with melorheostosis.
Kathleen Farrell, Leora E Comis, Morgan M Casimir and 5 others
PMID 35403375WHAT IT FOUND
In 45 adults with melorheostosis, high-demand leisure activities were least retained and often given up.
Physical fatigue was linked to lower activity retention, and lesion location was linked to extremity-specific function scores. Motivation and mental fatigue were not.
Key findings
01High-demand leisure activities had the lowest retained activity score, and important high-demand leisure activities were given up more often than important activities in other subdomains.
02Physical fatigue and reduced-activity fatigue scores were associated with lower high-demand leisure and overall activity retention, while reduced motivation and mental fatigue scores were not.
03Lesion location was associated with extremity-specific function scores: patients with lower-extremity lesions had lower lower-extremity function scores, and patients with upper-extremity lesions had lower upper-extremity function scores.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTs
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What it does not show
The study was cross-sectional and single-time-point, so it cannot show cause or how symptoms change over time. No treatment was tested, so it cannot support conclusions about therapy effectiveness. All measures were self-report and may be affected by recall bias. The sample was 45 adults from one institution, so it may not represent all people with melorheostosis. The function scales were skewed toward high independence and may miss small changes. The study did not determine why patients stopped activities, and it did not capture aging, economic hardship, or role changes. One patient with both upper and lower lesions was excluded from lesion-location analyses.
Declared interests
The authors declared no conflicts of interest. The article is listed as supported by NIH intramural research.
The easy way to misread this
Do not conclude that treating fatigue or the affected limb will increase activity participation. This was an observational cross-sectional study, not a treatment trial, and it did not prove what caused activity loss.