RNNarrative ReviewJournal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners2026

Monitoring Vaccine Safety: United States Vaccine Safety Surveillance Systems.

Lauren Head Zauche, Elaine R Miller, Sehwa S Kim and 2 others

PMID 41478707

WHAT IT FOUND

Pediatric nurses and nurse practitioners should familiarize themselves with U.S. vaccine safety surveillance systems like V-safe and VAERS to effectively address caregiver concerns and support vaccine confidence.

Key findings

01Pediatric providers should be familiar with vaccine safety surveillance systems to know where to seek resources when caregivers have questions or express concerns about vaccines.

02V-safe is a text-message-based active surveillance system that monitors postvaccination symptoms for select vaccines, including COVID-19 and RSV.

03VAERS is a passive reporting system that collects reports of adverse events following vaccination from anyone, including healthcare providers and patients, to detect possible safety signals.

STILL TO COME

How it was doneWhat they foundWhat it means for RNs

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What it does not show

This is a narrative review and does not present original data or a systematic search strategy. The content is descriptive and focuses on U.S. systems, limiting applicability to other national contexts. It does not evaluate the effectiveness of specific nurse-led interventions on vaccine confidence, only describing the systems nurses can use.

Declared interests

The authors declare no conflicts of interest.

The easy way to misread this

Do not use VAERS reports as evidence that a vaccine causes a specific adverse event. VAERS is a passive reporting system that detects potential signals but cannot determine causality or rates because it lacks an unvaccinated comparison group and suffers from underreporting and reporting bias.

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