Meta-analysis of ICU Delirium Biomarkers and Their Alignment With the NIA-AA Research Framework.
Carol K Chan, Yiqing Song, Ryan Greene and 5 others
PMID 34195769WHAT IT FOUND
Serum Aβ1-40, IL-RA, and IL-6 were linked with ICU delirium in pooled studies, but S100β and CRP were not.
Too few studies to change bedside care.
Key findings
01Pooled analyses found significant associations between ICU delirium and serum Aβ1-40, IL-RA, and IL-6.
02No study assessed pathologic tau biomarkers, and only 3 included β amyloid biomarkers.
03The meta-analysis included 38 studies, and all examined serum biomarkers.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
The analysis combined observational studies, so confounding factors cannot be ruled out. Only 38 of the initial 113 studies were included, and only 2 studies were included in the meta-analysis of 7 biomarkers. No study assessed pathologic tau biomarkers, and only 3 included β amyloid biomarkers, so the dementia framework comparison is incomplete. In one amyloid study, the delirium group was older than the control group, and amyloid can increase with age even without dementia.
The easy way to misread this
Do not treat Aβ1-40, IL-RA, or IL-6 as clinical biomarkers for ICU delirium. They came from few observational studies, and confounding cannot be ruled out.