PTOtherThe Journal of manual & manipulative therapy2026

Mechanosensitivity during straight leg raise and slump neurodynamic tests in people with type 1 diabetes mellitus and diabetic peripheral neuropathy.

Georgia Koutsoflini, Antonios Lepouras, Colette Ridehalgh

PMID 40792652

WHAT IT FOUND

Negative straight leg raise and slump tests were more common in people with severe diabetic neuropathy.

A negative test does not rule out neuropathy, so do not use these neurodynamic tests to screen for or exclude diabetic nerve damage.

Key findings

01Most participants with severe diabetic neuropathy had negative neurodynamic tests.

02Participants with negative straight leg raise or slump tests had significantly higher neuropathy severity scores than those with positive tests.

STILL TO COME

How it was doneWhat they foundWhat it means for PTs

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What it does not show

Small sample size (43 participants), which was below the calculated requirement for full statistical power. Four participants were included based on symptoms and TCSS scores without confirmed nerve conduction studies, risking misclassification. The same examiner performed both the neuropathy grading and the neurodynamic tests, which could introduce bias. No healthy control group was included to compare baseline mechanosensitivity.

Declared interests

The authors reported no funding or conflicts of interest.

The easy way to misread this

Do not interpret a negative neurodynamic test as evidence that a patient does not have diabetic neuropathy. The study found that negative tests were associated with more severe neuropathy, likely because the nerves are too damaged to respond to the mechanical stress of the test.

Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →