Integrative Review of Gut Microbiota and Expression of Symptoms Associated With Neonatal Abstinence Syndrome.
Stephanie D Sealschott, Rita H Pickler, Christine A Fortney and 1 others
PMID 32555010WHAT IT FOUND
Gut microbiota were linked to symptoms resembling NAS in 22 studies, but none studied infants with NAS.
This review cannot guide NAS care.
Key findings
01No included study was done in infants with NAS, so the review cannot establish that gut microbiota are associated with NAS symptoms.
02Diarrhea was assessed in ten included studies; in the seven intervention studies diarrhea decreased after intervention, and microbial variety increased in four.
03Abdominal pain was assessed in eight included studies; in the seven intervention studies pain decreased after intervention, and microbial variety increased in four.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
Read the rest of this summary
You get three full summaries a month, free, and we do not ask for a card. Search, the TL;DRs and your library stay unlimited either way.
What it does not show
No included study was done in infants with NAS. The 22 studies varied widely in populations, conditions, interventions, sequencing methods and analysis. Not all studies used best practices in microbiota analysis, such as normalizing sequencing data and controlling for false-positive errors. Not all studies reported alpha diversity, beta diversity and taxa abundance. Data extraction and evaluation were done by a single reviewer.
Declared interests
The supplied publication types indicate NIH extramural research support. The article text provided here does not include an author conflict-of-interest declaration.
The easy way to misread this
Do not conclude that gut microbiota cause or can guide treatment of NAS. The review included no infants with NAS, so it only describes associations in other conditions with similar symptoms.