Improving Developmental Abilities in Infants With Tuberous Sclerosis Complex: A Pilot Behavioral Intervention Study.

The study analyzed only five children, and three additional enrolled children did not complete required assessments or the entire intervention protocol, so the sample is very small and incomplete. The supplied text describes a single-group pilot intervention, so changes cannot be compared with what would have happened without the intervention. The authors used a qualitative, case-by-case description of MSEL changes rather than a group statistical test, so the result does not establish an effect size or a reliable average change. Several children had missing visits, including Case 1 missing postassessment and Case 5 missing follow-up, so the pattern across all time points is not complete. Children also had variable outside intervention hours, such as speech therapy ranging from 0.25 to 4 hr/week, and seizures were controlled during the study, so the contribution of JASPER alone cannot be separated. The families were highly educated, which may reflect a selection bias toward families with enough resources to travel and participate weekly. The intervention required in-person weekly sessions across a large geographic area, which may limit how easily the program can be used in routine practice. ADOS module changes for one child, and different baseline severity across children, make simple comparisons of score changes difficult.

The supplied text does not report funding or conflicts of interest.

Do not read the children's MSEL gains as evidence that JASPER caused them. The study analyzed five children in a single-group pilot, and the children also had variable outside intervention hours, such as speech therapy, and controlled seizures, so the contribution of JASPER cannot be separated.