Genotype, resilience and function and physical activity post hip fracture.
Barbara Resnick, N Jennifer Klinedinst, Laura Yerges-Armstrong and 5 others
PMID 31257007WHAT IT FOUND
At two months after hip fracture, resilience was associated with genetic variation and social activity, and with better function and more exercise.
The study cannot show cause.
Key findings
01Genetic variability and social activities were associated with resilience, accounting for 4 to 8% of the variance in resilience.
02Resilience, age, cognition, social activity, and pain intensity were directly associated with function, and genetic variability was indirectly associated through resilience.
03Resilience, age and cognition were directly associated with exercise, and genetic variability was indirectly associated through resilience.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for RNs
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What it does not show
The analysis was cross-sectional at two months, so it cannot show that genes, resilience, social activity or pain caused function or exercise differences. The sample was small and selected: community-dwelling, English-speaking, within 70 miles of a study hospital, weighing less than 300 pounds, and without contralateral hip hardware. The full models fit poorly, and simplified models were used. Exercise was self-reported or proxy-reported and may not reflect actual exercise. Multiple models were tested, so some significant paths could be chance.
Declared interests
The authors declared no conflicts of interest. The supplied text does not report a funding source.
The easy way to misread this
Do not conclude that genes, resilience or social activity cause better recovery. This was an observational analysis with poor model fit, and it did not test treatment.