Frontal brain activation changes due to dual-tasking under partial body weight support conditions in older adults with multiple sclerosis.

The MS group had 10 people and the healthy group had 12, so the results are small and may not represent older adults with MS. The groups were not matched: the MS group was younger and had lower physical function scores, which could affect brain activity. Support conditions were given in a fixed order, with no support before partial support, so learning or familiarisation could have influenced the results. This was a single session, not a training programme, so it cannot show lasting benefit or reduced falls. The treadmill was self-paced and the support system was new to participants, so higher brain activity may reflect novelty or learning rather than easier walking. Only the frontal brain region was measured, while walking involves many brain regions. Many statistical tests were run, so some positive findings could be false positives.

Do not conclude that partial body weight support improves walking while talking or reduces falls in older adults with multiple sclerosis. This was a single-session brain-activity study, not a treatment trial, and walking while talking was more demanding with support, so the finding may reflect novelty rather than benefit.