Factors associated with antiretroviral therapy interruption in hospitalized people living with HIV: a retrospective cohort.
Jarbas da Silva Ziani, Laís Mara Caetano da Silva Corcini, Jenifer Härter and 5 others
PMID 42184331WHAT IT FOUND
Among 208 hospitalized people with HIV, 82 had interrupted HIV medication.
Male sex, alcohol or other drug use, homelessness, longer travel to pick up medication, previous interruption, and late diagnosis were linked with interruption.
Key findings
01Of 208 final records, 82 (39.4%) had interrupted antiretroviral therapy, and the mean interruption time was 14.2 months.
02In adjusted analysis, male sex (adjusted PR 1.58; 95% CI 1.42-1.71), other drug use (adjusted PR 1.98; 95% CI 1.36-2.54), and travel time over 31 minutes (adjusted PR 1.67; 95% CI 1.13-1.89) remained associated with interruption, along with alcohol use disorder, homelessness, previous interruption, and late diagnosis.
03Tuberculosis/HIV coinfection was common but was not significantly associated with ART interruption (p = 0.092).
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
Retrospective medical-record data may be incomplete or underreported. The study was done in a reference hospital in Rio Grande do Sul, Brazil, with a likely concentration of more severe cases, so it may not generalize to other people with HIV. Because it used existing records, it cannot establish causality; the factors are associated with interruption, not proven causes. ART interruption was recorded from the specialized service as no pickup for more than 28 days plus no outpatient follow-up, which may miss people who missed visits but still took medication. Travel time was estimated with Google Maps under normal traffic, not actual journey conditions.
The easy way to misread this
Do not read these adjusted associations as proof that any factor caused ART interruption or that a nursing action will reduce interruption. The study is retrospective, single-center, and based on records, so it can only identify associations among hospitalized people with HIV.