Exploring the autism and functional neurological disorder association: Considerations from biopsychosocial, neuropsychological and computational models.
Richard H Cole, Lily Smythe, Mark J Edwards and 2 others
PMID 41403367WHAT IT FOUND
This theoretical review links autism and functional neurological disorder through shared traits like sensory overload and difficulty identifying emotions.
It suggests clinicians should screen for autism in FND patients to avoid misdiagnosis, but offers no tested interventions or outcome data.
Key findings
01The paper posits that autism and FND may share underlying vulnerabilities in interoception and emotion processing, rather than one causing the other.
02Authors argue that recognizing this association could help prevent misdiagnosis and reduce barriers to healthcare for autistic people with FND.
STILL TO COME
How it was doneWhat they foundWhat it means for PTsWhat it means for OTsWhat it means for SLPs
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What it does not show
This is a theoretical synthesis, not an empirical study. It proposes mechanisms but does not test them. The authors acknowledge that the evidence for impaired emotion concept granularity as a causal factor in FND remains speculative. There is a lack of data on the likelihood of autistic individuals with specific traits (like hypermobility or motor impairment) developing FND. The review notes that sensory processing definitions are inconsistent across studies, making direct comparisons difficult.
Declared interests
Funding was provided by The Wellington Hospital, the National Institute for Health and Care Research (NIHR), and the Medical Research Council (MRC). One author reports honoraria for textbooks and expert witness work. Another author holds shares in a private neurorehabilitation provider (Brain and Mind Ltd) and reports medicolegal work in FND.
The easy way to misread this
Do not interpret this paper as evidence that autism causes functional neurological disorder or that any specific treatment works. It is a theoretical model proposing shared vulnerabilities. Clinical changes should be based on existing evidence for FND and autism, not on this untested hypothesis.
Summarised by AI from the full paper, without a clinician reviewing it. Check it against the source before it changes what you do. Read it on PubMed →