Evaluation of respiratory complications in a cohort of preterm infants who did not receive palivizumab monoclonal antibodies.
Poliana Castro de Resende Bonati, Maria Cândida de Carvalho Furtado, Débora Falleiros de Mello and 3 others
PMID 36197428WHAT IT FOUND
Respiratory episodes were common in 504 preterm infants not eligible for palivizumab.
Unplanned visits tracked with more episodes, and formula feeding at discharge had a higher average count, though this study cannot prove cause.
Key findings
01Among 504 preterm infants not eligible for palivizumab, 356 had lower respiratory tract diseases, and 105 (29.5%) received a bronchiolitis diagnosis.
02As the number of sporadic appointments increased, the number of respiratory episodes also increased.
03Formula-fed infants had a higher average number of respiratory episodes at hospital discharge, but the diet comparison was not statistically significant.
STILL TO COME
How it was doneWhat they foundWhat it means for RNs
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What it does not show
The study used retrospective medical records, and missing data were present for maternal education, smoking, length of hospital stay, intensive care admission, respiratory diagnosis, and diet at discharge. It was based on one hospital and one municipality in Brazil, so findings may not apply elsewhere. Some infants had no first-year attendance records, so follow-up completeness varied. Because it was observational, it cannot show that formula feeding or sporadic visits caused respiratory episodes.
The easy way to misread this
Do not read formula feeding as the cause of more respiratory episodes. The formula group had a higher average count, but the difference was not statistically significant, and the study used past records without randomization.