Does sex influence the diagnostic evaluation of autism spectrum disorder in adults?
C Ellie Wilson, Clodagh M Murphy, Grainne McAlonan and 15 others
PMID 26802113WHAT IT FOUND
In adults first assessed for autism, more men than women received a diagnosis.
Men had more childhood repetitive interests. Social communication differences depended on whether the diagnosis was full or partial autism.
Key findings
0172% of men and 66% of women received a positive autism diagnosis.
02In high-functioning autism, men scored higher than women on childhood repetitive behaviours and restricted interests, and this was the only symptom difference that survived multiple comparison correction.
03Social and communication symptoms differed by autism subtype: men with full autism had higher scores than women, while women with partial autism had higher scores than men.
STILL TO COME
How it was doneWhat they foundWhat it means for SLPs
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What it does not show
Only adults being assessed for autism for the first time were included, so the findings may not apply to people diagnosed in childhood. Many participants did not have formal IQ testing, and analyses of symptom profiles excluded suspected or confirmed intellectual disability. The assessments were completed in one day, so some alternative conditions, such as attachment or personality disorder, were not fully assessed. The study did not measure true community prevalence or whether women are underdiagnosed; it only compared adults who reached a specialist clinic. The authors could not rule out that women have different, rather than fewer, repetitive interests, because the tools measure symptoms already included in the diagnosis.
Declared interests
The work was supported by the UK Medical Research Council, the EU Autism Imaging Study network, and the National Institute for Health Research Biomedical Research Centre for Mental Health at King’s College London and South London and Maudsley NHS Foundation Trust. The supplied text does not report author conflicts of interest.
The easy way to misread this
Do not read these results as proof that autism tests are biased against women or that women are underdiagnosed. The study only compared adults referred to one specialist clinic, and it did not measure how often autism exists in the general population.