Do physical activity and social cognitive theory variable scores differ across symptom cluster severity groups in multiple sclerosis?

This was a cross-sectional secondary analysis, so it cannot show whether severe symptom clusters reduce activity or whether low activity worsens symptoms. Device-measured activity did not differ by group, while self-reported activity did, so the two measures may not tell the same story. Valid accelerometer data were available for 184 of 205 participants, and Social Cognitive Theory data for 183 to 186, so some participants were missing from key analyses. Wear time differed nearly significantly between groups (F=5.32, p=0.06), which could affect device-measured activity. The groups differed in marital and employment status, which may be related to symptoms and activity. The sample was 76% female, 61% married, 57% employed and 65% Caucasian, so results may not apply to other groups. The symptom cluster was based on fatigue, depression, anxiety and sleep only, not mobility or cognitive symptoms.

The authors report no conflicts of interest. The supplied article metadata lists NIH and non-U.S. government research support, but the text does not state a funding source or sponsor role.

Do not conclude that more severe symptom clusters cause lower physical activity or that device-measured activity falls with severity. The study was cross-sectional, and device-measured light and moderate-vigorous activity did not differ significantly across severity groups.