Corticospinal Tract Lesion Load Originating From Both Ventral Premotor and Primary Motor Cortices Are Associated With Post-stroke Motor Severity.
Kaori L Ito, Bokkyu Kim, Jingchun Liu and 6 others
PMID 34951947WHAT IT FOUND
Lesion overlap with corticospinal fibers from ventral premotor cortex and primary motor cortex was linked to severe versus mild motor impairment after stroke.
The ventral premotor tract added information beyond primary motor cortex alone.
Key findings
01CST lesion load from ventral premotor cortex and primary motor cortex was associated with severe versus mild FMA groups.
02A model including both M1 and PMv fit better than a model with M1 only.
03Adding SMA to M1 did not significantly improve fit, and total lesion volume did not explain the finding.
STILL TO COME
How it was doneWhat they foundWhat it means for PTs
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What it does not show
The design was cross-sectional, multi-site, and retrospective, so cohort effects and limited generalizability are possible. The FMA groups were imbalanced, with mild 77, moderate 21, and severe 40. The analysis was an association with FMA severity groups, not a treatment outcome or longitudinal recovery study.
Declared interests
One author, SC, is a consultant for Abbvie, Constant Therapeutics, MicroTransponder, Neurolutions, SanBio, Panaxium, NeuExcell, Elevian, Medtronic, and TRCare. No other conflicts of interest were declared. The article is categorized as NIH extramural research support.
The easy way to misread this
Do not conclude that ventral premotor tract injury causes worse motor severity or that PMv-specific therapy will improve function. This was a cross-sectional imaging association with FMA groups, not a treatment or longitudinal outcome study.